Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 6/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | GLS | O94925 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CPT2 | P23786 | 1/20 | 0.33 |
| ▸ | CPT1A | P50416 | 1/20 | 0.33 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27978490 | 0.92 | PTPN11 (0.38) | PTPN11HPGDALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL27978780 | 0.91 | MAPT (0.37) | PTPN11HPGDALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL14965244 | 0.81 | HTR1A (0.38) | KDM4E | |
| SCHEMBL27978487 | 0.80 | PTPN11 (0.33) | PTPN11HPGDALDH1A1MEN1CYP2C9 | |
| SCHEMBL27978494 | 0.77 | SMN1; SMN2 (0.39) | SMN1; SMN2KDM4EKMT2ATP53 | |
| SCHEMBL27978691 | 0.74 | ADRB3 (0.41) | MEN1KMT2A | |
| SCHEMBL27978717 | 0.72 | SMN1; SMN2 (0.38) | POLBSMN1; SMN2HTTKMT2A | |
| SCHEMBL14965345 | 0.72 | HTR2A (0.36) | KDM4E | |
| SCHEMBL27978714 | 0.71 | ELANE (0.34) | ALDH1A1MAPT | |
| SCHEMBL27978447 | 0.70 | KMT2A (0.42) | HPGDALDH1A1SMN1; SMN2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104011054-A | Thieno- and furo-pyrimidines and pyridines, useful as potassium channel inhibitors | XENTION LTD | 2014-08-27 | — | — | CN | disclosed |