Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 5/20 | 0.38 |
| ▸ | APEX1 | P27695 | 2/20 | 0.35 |
| ▸ | CKS1B | P61024 | 2/20 | 0.35 |
| ▸ | SKP1 | P63208 | 2/20 | 0.35 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | GLS | O94925 | 2/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27978468 | 0.92 | PTPN11 (0.37) | PTPN11MAPTPOLBP2RY12GLS | |
| SCHEMBL27978780 | 0.91 | MAPT (0.37) | PTPN11MAPTPOLBP2RY12GLS | |
| SCHEMBL27978691 | 0.82 | ADRB3 (0.41) | MEN1KMT2A | |
| SCHEMBL27978487 | 0.81 | PTPN11 (0.33) | PTPN11P2RY12MEN1ALDH1A1CYP2C9 | |
| SCHEMBL14965345 | 0.79 | HTR2A (0.36) | KDM4E | |
| SCHEMBL27978494 | 0.78 | SMN1; SMN2 (0.39) | KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL27978717 | 0.73 | SMN1; SMN2 (0.38) | POLBHTTKMT2ASMN1; SMN2 | |
| SCHEMBL14965244 | 0.73 | HTR1A (0.38) | KDM4E | |
| SCHEMBL27978447 | 0.72 | KMT2A (0.42) | MAPTKDM4EMEN1ALDH1A1HPGD | |
| SCHEMBL27978716 | 0.70 | MAPT (0.35) | MAPTMEN1ALDH1A1CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104011054-A | Thieno- and furo-pyrimidines and pyridines, useful as potassium channel inhibitors | XENTION LTD | 2014-08-27 | — | — | CN | disclosed |