Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.62 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | PARP1 | P09874 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | RECQL | P46063 | 1/20 | 0.60 |
| ▸ | BLM | P54132 | 1/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | DHODH | Q02127 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27626919 | 0.91 | MKNK1 (0.71) | MKNK1MKNK2MAPTL3MBTL1CYP2C19 | |
| SCHEMBL153199 | 0.91 | MKNK1 (0.71) | MKNK1MKNK2MAPTL3MBTL1CYP2C19 | |
| Fluoromethane SCHEMBL28145184 | 0.89 | MKNK1 (0.65) | MKNK1MKNK2MAPTL3MBTL1CYP2C19 | |
| Iodide SCHEMBL30131442 | 0.89 | MKNK1 (0.69) | MKNK1MKNK2MAPTL3MBTL1CYP2C19 | |
| Hydrochloric Acid SCHEMBL7913500 | 0.89 | MKNK1 (0.69) | MKNK1MKNK2MAPTL3MBTL1CYP2C19 | |
| Benzamide SCHEMBL5070344 | 0.89 | MAPT (0.76) | MKNK1MKNK2MAPTL3MBTL1CYP2C19 | |
| Hydrochloric Acid SCHEMBL22441935 | 0.87 | MKNK1 (0.67) | MKNK1MKNK2MAPTL3MBTL1CYP2C19 | |
| Benzamide SCHEMBL3897344 | 0.87 | PARP1 (0.80) | MAPTL3MBTL1CYP2C19HSD17B10POLB | |
| SCHEMBL27446284 | 0.85 | MKNK1 (0.76) | MKNK1MKNK2MAPTL3MBTL1CYP2C19 | |
| Benzamide SCHEMBL27929288 | 0.85 | PARP1 (0.76) | MAPTL3MBTL1CYP2C19HSD17B10POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104024253-A | Heterocyclic amines as PI3K inhibitors | INCYTE CORP | 2014-09-03 | — | — | CN | claimed |
| CN-104024253-A | Heterocyclic amines as PI3K inhibitors | INCYTE CORP | 2014-09-03 | — | — | CN | disclosed |