Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 9/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | F2R | P25116 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | CDK4 | P11802 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10010193 | 1.00 | P2RX7 (0.33) | P2RX7EGFRERBB3MAPK1ROCK2 | |
| SCHEMBL10009201 | 1.00 | P2RX7 (0.33) | P2RX7EGFRERBB3MAPK1ROCK2 | |
| SCHEMBL10009040 | 0.88 | P2RX7 (0.36) | P2RX7MAPK1JAK2 | |
| SCHEMBL1506170 | 0.88 | GSK3B (0.41) | MAPK1CDK4CDK2 | |
| SCHEMBL1506141 | 0.88 | GSK3B (0.41) | MAPK1CDK4CDK2 | |
| SCHEMBL1506232 | 0.87 | EGFR (0.35) | P2RX7EGFRERBB3MAPK1TGFBR1 | |
| SCHEMBL10010256 | 0.85 | MAPK1 (0.41) | EGFRMAPK1TGFBR1CDK4CDK2 | |
| SCHEMBL1506191 | 0.84 | EGFR (0.34) | P2RX7EGFRERBB3MAPK1TGFBR1 | |
| SCHEMBL1506150 | 0.83 | P2RX7 (0.37) | P2RX7EGFRERBB3MAPK1FGFR1 | |
| SCHEMBL1506194 | 0.83 | RXRA (0.41) | P2RX7EGFRERBB3MAPK1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102574832-B | Substituted N-phenyl-1-(4-pyridinyl)-1H-pyrazol-3-amines | JANSSEN PHARMACEUTICA NV | 2014-09-24 | — | — | CN | disclosed |