Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.49 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.47 |
| ▸ | HTR3B | O95264 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.47 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 5/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27981550 | 0.97 | HRH3 (0.50) | HRH3HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL17315088 | 0.82 | HRH3 (0.55) | HRH3HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL221140 | 0.81 | NOS3 (0.58) | HRH3HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL27981548 | 0.81 | PTPN1 (0.48) | HRH3KCNH2LTA4HKDM4EALDH1A1 | |
| SCHEMBL27981874 | 0.80 | KDM4E (0.55) | HRH3HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL27981875 | 0.80 | KDM4E (0.46) | HRH3HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL221954 | 0.79 | NOS3 (0.58) | HRH3HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL27981840 | 0.78 | KDM4E (0.47) | HRH3HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL218605 | 0.78 | NOS3 (0.59) | HRH3HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL27981564 | 0.78 | LTA4H (0.48) | HRH3HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101316853-B | Benzothiazole and thiazolopyridine as SIRTUIN modulators | SIRTRIS PHARMACEUTICALS INC | 2014-09-24 | — | — | CN | disclosed |