Altretamine

Altretamine

SCHEMBL2798192

CN(C)c1nc(N(C)C)nc(N(C)C)n1.O=C1NC2NC(=O)NC2N1

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.52
CYP1A2 P05177 1/20 0.52
THRB P10828 1/20 0.52
BLM P54132 1/20 0.52
CREBBP Q92793 1/20 0.52
HSD17B10 Q99714 1/20 0.52
POLB P06746 1/20 0.38
ALDH1A1 P00352 5/20 0.37
KDM4E B2RXH2 2/20 0.37
HPGD P15428 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.36
HTT P42858 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.31
TSHR P16473 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL36249 0.72 MAPT (0.39) TSHR
SCHEMBL36250 0.72 MAPT (0.39) TSHR
Altretamine SCHEMBL2354769 0.72 LMNA (1.00) LMNACYP1A2THRBBLMCREBBP
Altretamine SCHEMBL4206 0.72 LMNA (1.00) LMNACYP1A2THRBBLMCREBBP
Altretamine SCHEMBL28400006 0.70 LMNA (0.79) LMNACYP1A2THRBBLMCREBBP
Methyl Alcohol SCHEMBL11771953 0.70 TDP1 (0.35) KDM4ETSHR
Altretamine SCHEMBL29131538 0.69 LMNA (0.92) LMNACYP1A2THRBBLMCREBBP
Methane SCHEMBL3171277 0.69 MAPT (0.37) TSHR
Altretamine SCHEMBL11746235 0.69 LMNA (0.92) LMNACYP1A2THRBBLMCREBBP
Methoxymethane SCHEMBL1711287 0.68 ABL1 (0.34) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9640396-B2 Spin-on spacer materials for double- and triple-patterning lithography BREWER SCIENCE INC. (US) 2017-05-02 US disclosed
US-20100170868-A1 SPIN-ON SPACER MATERIALS FOR DOUBLE- AND TRIPLE-PATTERNING LITHOGRAPHY BREWER SCIENCE INC. (US) 2010-07-08 US disclosed