Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | MMP14 | P50281 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7298528 | 0.84 | TSHR (0.50) | MAPTALDH1A1RAB9AHTTGAA | |
| SCHEMBL11006035 | 0.84 | TSHR (0.50) | MAPTALDH1A1RAB9AHTTGAA | |
| SCHEMBL11836225 | 0.84 | ALDH1A1 (0.56) | MAPTALDH1A1RAB9AHTTGAA | |
| SCHEMBL11836212 | 0.84 | ALDH1A1 (0.56) | MAPTALDH1A1RAB9AHTTGAA | |
| SCHEMBL13602996 | 0.83 | MAPT (0.46) | MAPTALDH1A1RAB9AHTTGAA | |
| SCHEMBL3941257 | 0.83 | MAPT (0.39) | MAPTALDH1A1RAB9AHTTGAA | |
| SCHEMBL2625725 | 0.83 | MAPT (0.39) | MAPTALDH1A1RAB9AHTTGAA | |
| SCHEMBL14609881 | 0.83 | MAPT (0.39) | MAPTALDH1A1RAB9AHTTGAA | |
| SCHEMBL7408714 | 0.81 | PRMT1 (0.49) | MAPTALDH1A1RAB9AGAAMMP14 | |
| SCHEMBL7408707 | 0.81 | PRMT1 (0.49) | MAPTALDH1A1RAB9AGAAMMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102482221-B | bicyclic and tricyclic compounds as KATII inhibitors | PFIZER INC. (US) | 2014-10-22 | — | — | CN | disclosed |