Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ASPH | Q12797 | 1/20 | 0.38 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 2/20 | 0.35 |
| ▸ | CES1 | P23141 | 2/20 | 0.35 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.33 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.33 |
| ▸ | ALB | P02768 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
| ▸ | RARB | P10826 | 2/20 | 0.32 |
| ▸ | RARA | P10276 | 1/20 | 0.32 |
| ▸ | RARG | P13631 | 1/20 | 0.32 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL974928 | 0.86 | KDM4E (0.41) | KDM4EASPHKDM8CYP1A2CES2 | |
| SCHEMBL27600988 | 0.84 | KDM4E (0.35) | KDM4EASPHKDM8CYP1A2ALDH1A1 | |
| SCHEMBL27912539 | 0.84 | MRGPRX4 (0.46) | FOLH1ALBALDH1A1ALOX15MRGPRX4 | |
| SCHEMBL9406148 | 0.81 | RARB (0.41) | KDM4EASPHKDM8CYP1A2CES2 | |
| SCHEMBL28785054 | 0.80 | ALDH1A1 (0.40) | KDM4ECES2CES1ALDH1A1MRGPRX4 | |
| SCHEMBL9419244 | 0.79 | GABRP (0.46) | RARBRARARARG | |
| SCHEMBL5248959 | 0.79 | GABRP (0.42) | KDM4EASPHKDM8CYP1A2CES2 | |
| SCHEMBL542766 | 0.79 | KDM4E (0.41) | KDM4EASPHKDM8CYP1A2CES2 | |
| SCHEMBL9419332 | 0.77 | RARB (0.51) | ALOX15RARBRARARARG | |
| SCHEMBL27985838 | 0.77 | TSHR (0.46) | KDM4EALDH1A1MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104105691-A | MODULATORS OF THE G PROTEIN-COUPLED MAS RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARM INC | 2014-10-15 | — | — | CN | disclosed |