Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.33 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.33 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | DNM1 | Q05193 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6863232 | 0.98 | TSHR (0.66) | TSHRTHRBPOLBAPEX1HTT | |
| Hydrochloric Acid SCHEMBL27656623 | 0.98 | TSHR (0.66) | TSHRTHRBPOLBAPEX1HTT | |
| Hydrochloric Acid SCHEMBL27656702 | 0.98 | TSHR (0.66) | TSHRTHRBPOLBAPEX1HTT | |
| Bromide SCHEMBL4592298 | 0.97 | TSHR (0.64) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL3269103 | 0.95 | TSHR (0.59) | TSHRTHRBPOLBAPEX1HTT | |
| Hydrochloric Acid SCHEMBL475736 | 0.95 | TSHR (0.59) | TSHRTHRBPOLBAPEX1HTT | |
| Bromide SCHEMBL352220 | 0.93 | TSHR (0.58) | TSHRTHRBPOLBAPEX1HTT | |
| Bromide SCHEMBL9494989 | 0.89 | TSHR (0.73) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL23375504 | 0.88 | TSHR (0.56) | TSHRTHRBPOLBAPEX1HTT | |
| SCHEMBL5418018 | 0.87 | TSHR (0.49) | TSHRTHRBPOLBAPEX1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100168282-A1 | DISPERSION COMPRISING INORGANIC PARTICLES, WATER, AND AT LEAST ONE POLYMERIC ADDITIVE | EVONIK ROEHM GMBH (DE) | 2010-07-01 | — | — | US | disclosed |