Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.43 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 1/20 | 0.41 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.41 |
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.41 |
| ▸ | SCN1A | P35498 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | CPA1 | P15085 | 1/20 | 0.40 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.40 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27947274 | 0.94 | DPP4 (0.44) | KMT2APPARAFOLH1PTGER1PTGER4 | |
| Phosphoric Acid SCHEMBL14714940 | 0.91 | KMT2A (0.43) | KMT2APPARAFOLH1PTGER1PTGER4 | |
| Bicarbonate SCHEMBL27570622 | 0.87 | CYSLTR2 (0.47) | PPARACYSLTR2CYSLTR1LTB4RBID | |
| SCHEMBL6527163 | 0.87 | DPP4 (0.47) | KMT2APPARAFOLH1PTGER1PTGER4 | |
| Bicarbonate SCHEMBL27543186 | 0.83 | PPARA (0.57) | PPARACYSLTR2CYSLTR1BIDBCL2L1 | |
| Bicarbonate SCHEMBL27513992 | 0.83 | PPARA (0.57) | PPARACYSLTR2CYSLTR1BIDBCL2L1 | |
| Bicarbonate SCHEMBL1835039 | 0.83 | PPARA (0.57) | PPARACYSLTR2CYSLTR1BIDBCL2L1 | |
| Bicarbonate SCHEMBL1838555 | 0.83 | PPARA (0.57) | PPARACYSLTR2CYSLTR1BIDBCL2L1 | |
| Bicarbonate SCHEMBL27594350 | 0.83 | PPARA (0.57) | PPARACYSLTR2CYSLTR1BIDBCL2L1 | |
| Bicarbonate SCHEMBL1839396 | 0.83 | PPARA (0.57) | PPARACYSLTR2CYSLTR1BIDBCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102093684-B | Polycarbonate Alloys with highly resistance deformability and improved surface property | 科思创德国股份有限公司 | 2019-04-05 | — | — | CN | disclosed |
| CN-107207846-A | The copolycarbonate composition for including double glyceride with improved rheology and optical property | 科思创德国股份有限公司 | 2017-09-26 | — | — | CN | disclosed |
| CN-107207845-A | Copolycarbonate compositions comprising PE-waxes with improved processability | 科思创德国股份有限公司 | 2017-09-26 | — | — | CN | disclosed |
| CN-104540890-A | Products with improved non-flammability | BAYER MATERIALSCIENCE AG | 2015-04-22 | — | — | CN | disclosed |
| CN-102101839-B | Polycarbonate with improved thermal and mechanical properties and reduced thermal expansion coefficient | BAYER MATERIALSCIENCE AG | 2014-12-24 | — | — | CN | disclosed |