Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.47 |
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.47 |
| ▸ | LTB4R | Q15722 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | BID | P55957 | 4/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.41 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.41 |
| ▸ | BAK1 | Q16611 | 3/20 | 0.41 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.41 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.41 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.41 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7632660 | 0.90 | HIF1A (0.43) | CYSLTR2CYSLTR1LTB4RLMNAHIF1A | |
| SCHEMBL30899680 | 0.90 | HIF1A (0.43) | CYSLTR2CYSLTR1LTB4RLMNAHIF1A | |
| Bicarbonate SCHEMBL27580598 | 0.90 | MGLL (0.50) | CYSLTR2CYSLTR1BIDMCL1BCL2L1 | |
| SCHEMBL7637528 | 0.88 | HIF1A (0.41) | CYSLTR2CYSLTR1LMNAHIF1AEPAS1 | |
| Phosphoric Acid SCHEMBL28716195 | 0.87 | ALDH1A1 (0.46) | CYSLTR2CYSLTR1LTB4RHIF1AEPAS1 | |
| Bicarbonate SCHEMBL27989644 | 0.87 | KMT2A (0.49) | CYSLTR2CYSLTR1LTB4RBIDMCL1 | |
| SCHEMBL11803993 | 0.87 | LIPG (0.42) | CYSLTR2CYSLTR1LTB4RHIF1AEPAS1 | |
| SCHEMBL28356255 | 0.87 | LIPG (0.42) | CYSLTR2CYSLTR1LTB4RHIF1AEPAS1 | |
| SCHEMBL28352315 | 0.87 | LIPG (0.42) | CYSLTR2CYSLTR1LTB4RHIF1AEPAS1 | |
| SCHEMBL480252 | 0.86 | SLC16A3 (0.53) | CYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104540890-A | Products with improved non-flammability | BAYER MATERIALSCIENCE AG | 2015-04-22 | — | — | CN | disclosed |
| CN-102093685-A | Polycarbonate compositions with improved surface hardness | BAYER MATERIALSCIENCE AG | 2011-06-15 | — | — | CN | disclosed |
| CN-102002224-A | Products with improved flame retardancy | BAYER MATERIALSCIENCE AG | 2011-04-06 | — | — | CN | disclosed |
| CN-100448912-C | Method for producing polyester carbonic ester | BAYER AG (DE) | 2009-01-07 | — | — | CN | disclosed |
| CN-100434453-C | Polycarbonates, polyester carbonates and polyesters containing pendant cycloalkyl-substituted phenols | BAYER MATERIALSCIENCE AG (DE) | 2008-11-19 | — | — | CN | disclosed |
| CN-1729227-A | Polycarbonates, polyester carbonates and polyesters containing pendant cycloalkyl-substituted phenols | BAYER MATERIALSCIENCE AG (DE) | 2006-02-01 | — | — | CN | disclosed |
| CN-1412219-A | Method for producing polyester carbonic ester | BAYER AG (DE) | 2003-04-23 | — | — | CN | disclosed |