Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.42 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naphthalene SCHEMBL28012217 | 0.92 | MEN1 (0.40) | TSHRNAPRTDAOSRD5A2KDM4E | |
| Terephthalic Acid SCHEMBL28044877 | 0.91 | TSHR (0.48) | TSHRNAPRTDAOSRD5A2CES2 | |
| Benzoic Acid SCHEMBL17495601 | 0.90 | NAPRT (0.54) | TSHRNAPRTDAOSRD5A2CES2 | |
| Terephthalic Acid SCHEMBL27990724 | 0.89 | TSHR (0.50) | TSHRNAPRTDAOSRD5A2CES2 | |
| Terephthalic Acid SCHEMBL28067237 | 0.89 | TSHR (0.45) | TSHRNAPRTDAOSRD5A2CES2 | |
| Terephthalic Acid SCHEMBL28005997 | 0.88 | TSHR (0.48) | TSHRNAPRTDAOSRD5A2CES2 | |
| Terephthalic Acid SCHEMBL28013542 | 0.88 | TSHR (0.48) | TSHRNAPRTDAOSRD5A2CES2 | |
| Terephthalic Acid SCHEMBL28065968 | 0.88 | TSHR (0.48) | TSHRNAPRTDAOSRD5A2CES2 | |
| Benzoic Acid SCHEMBL380582 | 0.83 | NAPRT (0.47) | TSHRNAPRTDAOSRD5A2CES2 | |
| Terephthalic Acid SCHEMBL28600607 | 0.83 | TSHR (0.43) | TSHRNAPRTDAOSRD5A2CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104610299-A | Zinc naphthalene bistriazole terephthalic acid complex used as potential fluorescent material and preparation method thereof | UNIV TIANJIN NORMAL | 2015-05-13 | — | — | CN | disclosed |
| CN-104610299-A | Zinc naphthalene bistriazole terephthalic acid complex used as potential fluorescent material and preparation method thereof | UNIV TIANJIN NORMAL | 2015-05-13 | — | — | CN | disclosed |