Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.45 |
| ▸ | DAO | P14920 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.44 |
| ▸ | CES2 | O00748 | 2/20 | 0.44 |
| ▸ | CES1 | P23141 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL17495601 | 0.92 | NAPRT (0.54) | TSHRNAPRTDAOSRD5A2CES2 | |
| Terephthalic Acid SCHEMBL28044877 | 0.90 | TSHR (0.48) | TSHRNAPRTDAOSRD5A2CES2 | |
| Terephthalic Acid SCHEMBL27990425 | 0.89 | TSHR (0.42) | TSHRNAPRTDAOSRD5A2CES2 | |
| Terephthalic Acid SCHEMBL27990724 | 0.88 | TSHR (0.50) | TSHRNAPRTDAOSRD5A2CES2 | |
| SCHEMBL27970673 | 0.88 | KMT2A (0.33) | TSHRNAPRTDAOCES2CES1 | |
| SCHEMBL28061261 | 0.88 | KMT2A (0.33) | TSHRNAPRTDAOCES2CES1 | |
| Terephthalic Acid SCHEMBL28005997 | 0.86 | TSHR (0.48) | TSHRNAPRTDAOSRD5A2CES2 | |
| Terephthalic Acid SCHEMBL28013542 | 0.86 | TSHR (0.48) | TSHRNAPRTDAOSRD5A2CES2 | |
| SCHEMBL28016232 | 0.86 | MEN1 (0.32) | TSHRNAPRTDAOCES2CES1 | |
| Terephthalic Acid SCHEMBL28065968 | 0.86 | TSHR (0.48) | TSHRNAPRTDAOSRD5A2CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105524086-A | Potential fluorescent material tetraphenyl ethylene tetra-triazole terephthalic acid zinc complex and preparation method thereof | UNIV TIANJIN | 2016-04-27 | — | — | CN | disclosed |
| CN-105524086-A | Potential fluorescent material tetraphenyl ethylene tetra-triazole terephthalic acid zinc complex and preparation method thereof | UNIV TIANJIN | 2016-04-27 | — | — | CN | disclosed |