SCHEMBL27994161

SCHEMBL27994161

FC(F)(Cl)c1ccccc1C(Cl)Cl

nearest known ligand 0.36

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
P2RX7 Q99572 1/20 0.36
ACP3 P15309 1/20 0.33
TSHR P16473 1/20 0.33
IDO1 P14902 1/20 0.31
TDO2 P48775 1/20 0.31
CNR2 P34972 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29523337 0.84 ACP3 (0.46) P2RX7ACP3TSHRIDO1TDO2
SCHEMBL6564259 0.84 ACP3 (0.46) P2RX7ACP3TSHRIDO1TDO2
SCHEMBL29522913 0.81 TSHR (0.36) P2RX7TSHR
SCHEMBL10493638 0.81 TSHR (0.36) P2RX7TSHR
SCHEMBL1845725 0.81 TSHR (0.36) P2RX7TSHR
SCHEMBL4204805 0.77 TSHR (0.38) P2RX7TSHRIDO1
SCHEMBL10892336 0.74 TSHR (0.41) TSHR
SCHEMBL3785333 0.71 TSHR (0.50) TSHRIDO1TDO2
SCHEMBL11722237 0.70 ALDH1A1 (0.43) P2RX7TSHRIDO1
SCHEMBL10968544 0.70 IDO1 (0.36) P2RX7IDO1TDO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103274929-B Preparation method of 2-trifluoromethyl benzoic acid KINGCHEM LIAONING CHEMICAL CO LTD 2014-12-17 CN claimed
CN-103274929-B Preparation method of 2-trifluoromethyl benzoic acid KINGCHEM LIAONING CHEMICAL CO LTD 2014-12-17 CN disclosed