Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 7/20 | 0.78 |
| ▸ | MAPT | P10636 | 4/20 | 0.74 |
| ▸ | CDC7 | O00311 | 9/20 | 0.74 |
| ▸ | DBF4 | Q9UBU7 | 9/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.70 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.70 |
| ▸ | CRHBP | P24387 | 1/20 | 0.70 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15049004 | 0.88 | TRPM8 (1.00) | TRPM8MAPTCDC7DBF4MEN1 | |
| SCHEMBL27997093 | 0.87 | CDC7 (0.74) | TRPM8MAPTCDC7DBF4MEN1 | |
| SCHEMBL15048955 | 0.85 | TRPM8 (1.00) | TRPM8MAPTCDC7DBF4MEN1 | |
| SCHEMBL15049060 | 0.85 | TRPM8 (0.80) | TRPM8MAPTCDC7DBF4MEN1 | |
| SCHEMBL15049096 | 0.85 | TRPM8 (1.00) | TRPM8MAPTCDC7DBF4MEN1 | |
| SCHEMBL6338322 | 0.85 | TRPM8 (1.00) | TRPM8MAPTCDC7DBF4MEN1 | |
| SCHEMBL5240574 | 0.84 | CDC7 (1.00) | TRPM8MAPTCDC7DBF4MEN1 | |
| SCHEMBL15048995 | 0.83 | TRPM8 (0.76) | TRPM8MAPTCDC7DBF4MEN1 | |
| SCHEMBL28245895 | 0.82 | TRPM8 (0.58) | TRPM8MAPTCDC7DBF4MEN1 | |
| SCHEMBL8868073 | 0.81 | TRPM8 (0.73) | TRPM8MAPTCDC7DBF4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104220069-B | Trpm8 antagonists | 多姆皮制药公司 | 2018-10-02 | — | — | CN | disclosed |
| CN-104220069-A | Trpm8 antagonists | DOMPE SPA | 2014-12-17 | — | — | CN | disclosed |