Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27749291 | 0.81 | ALDH1A1 (0.43) | GRM5ALDH1A1LMNAHPGDGAA | |
| SCHEMBL12247671 | 0.79 | GRM5 (0.49) | GRM5ALDH1A1LMNADDB1CRBN | |
| SCHEMBL28376153 | 0.79 | KDM4E (0.45) | ALDH1A1LMNAKDM4EHPGDHSD17B10 | |
| SCHEMBL5366242 | 0.76 | DDB1 (0.44) | GRM5ALDH1A1DDB1CRBNKDM4E | |
| SCHEMBL11856799 | 0.76 | GRM5 (0.43) | GRM5ALDH1A1LMNADDB1CRBN | |
| SCHEMBL2378788 | 0.76 | GRM5 (0.43) | GRM5ALDH1A1LMNADDB1CRBN | |
| SCHEMBL14007394 | 0.74 | SMN1; SMN2 (0.48) | GRM5ALDH1A1LMNADDB1CRBN | |
| SCHEMBL27636191 | 0.74 | HSD11B1 (0.49) | ALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL5374700 | 0.73 | GRM5 (0.41) | GRM5ALDH1A1LMNADDB1CRBN | |
| SCHEMBL12376830 | 0.73 | ALDH1A1 (0.47) | ALDH1A1LMNAKDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102791714-B | N-(imidazopyrimidin-7-yl)-heteroarylamide derivatives and their use as PDE10A inhibitors | HOFFMANN LA ROCHE | 2015-03-25 | — | — | CN | claimed |
| CN-102791714-B | N-(imidazopyrimidin-7-yl)-heteroarylamide derivatives and their use as PDE10A inhibitors | HOFFMANN LA ROCHE | 2015-03-25 | — | — | CN | disclosed |