Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.56 |
| ▸ | S100A4 | P26447 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | CDC25B | P30305 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 5/20 | 0.39 |
| ▸ | MAOA | P21397 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | APAF1 | O14727 | 2/20 | 0.39 |
| ▸ | TDP2 | O95551 | 2/20 | 0.39 |
| ▸ | CES1 | P23141 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | PTPRC | P08575 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3273421 | 0.74 | SLC2A1 (0.96) | SLC2A1S100A4MEN1KMT2ACDC25B | |
| Hydrochloric Acid SCHEMBL29365758 | 0.72 | SLC2A1 (1.00) | SLC2A1S100A4MEN1KMT2ACDC25B | |
| Hydrochloric Acid SCHEMBL3343803 | 0.72 | SLC2A1 (1.00) | SLC2A1S100A4MEN1KMT2ACDC25B | |
| SCHEMBL7997569 | 0.69 | SLC2A1 (0.57) | SLC2A1S100A4MEN1KMT2ACDC25B | |
| Anthraquinone SCHEMBL25230500 | 0.63 | MEN1 (0.86) | S100A4MEN1KMT2ACDC25BMAPT | |
| SCHEMBL23422731 | 0.63 | SLC2A1 (0.48) | SLC2A1S100A4MEN1KMT2ACDC25B | |
| Anthraquinone SCHEMBL14943 | 0.62 | MEN1 (1.00) | S100A4MEN1KMT2ACDC25BMAPT | |
| Anthraquinone SCHEMBL29358690 | 0.62 | MEN1 (1.00) | S100A4MEN1KMT2ACDC25BMAPT | |
| Anthraquinone SCHEMBL1901249 | 0.62 | MEN1 (1.00) | S100A4MEN1KMT2ACDC25BMAPT | |
| SCHEMBL1477146 | 0.62 | S100A4 (0.75) | SLC2A1S100A4MEN1KMT2ACDC25B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8598146-B2 | Methods for identifying modulators of protein kinase C-epsilon (PKCε) and method of treatment of aberrant glucose metabolism associated therewith | GARVAN INSTITUTE OF MEDICAL RESEARCH (AU) | 2013-12-03 | — | — | US | disclosed |
| EP-2228069-A1 | Antagonists of protein kinase c-epsilon (pkcepsilon) and their use for the treatment of aberrant glucose metabolism associated therewith. | GARVAN INSTITUTE OF MEDICAL RESEARCH (AU) | 2010-09-15 | — | — | EP | disclosed |
| US-20080263689-A1 | Screening/monitoring rate of internalization of insulin receptors in insulin-stimulated hepatocytes; identifying modulators of insulin clearance and secretion; treating insulin resistance | GARVAN INSTITUTE OF MEDICAL RESEARCH (AU) | 2008-10-23 | — | — | US | disclosed |