Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 20/20 | 0.61 |
| ▸ | CRHR2 | Q13324 | 5/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27998886 | 1.00 | CRHR1 (0.61) | CRHR1CRHR2 | |
| SCHEMBL1849474 | 0.88 | CRHR1 (0.59) | CRHR1CRHR2 | |
| SCHEMBL1849475 | 0.88 | CRHR1 (0.59) | CRHR1CRHR2 | |
| SCHEMBL24405389 | 0.87 | CRHR1 (0.64) | CRHR1CRHR2 | |
| SCHEMBL27816992 | 0.86 | CRHR1 (0.63) | CRHR1CRHR2 | |
| SCHEMBL21474035 | 0.85 | CRHR1 (0.61) | CRHR1CRHR2 | |
| SCHEMBL1850200 | 0.84 | CRHR1 (0.70) | CRHR1CRHR2 | |
| SCHEMBL1850199 | 0.84 | CRHR1 (0.70) | CRHR1CRHR2 | |
| SCHEMBL30615456 | 0.84 | CRHR1 (0.70) | CRHR1CRHR2 | |
| SCHEMBL2317531 | 0.84 | CRHR1 (0.60) | CRHR1CRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102753527-B | Cyclohexyl amide derivatives as crf receptor antagonists | NOVARTIS AG | 2014-12-24 | — | — | CN | disclosed |
| CN-102753527-A | Cyclohexyl amide derivatives as crf receptor antagonists | NOVARTIS AG | 2012-10-24 | — | — | CN | disclosed |
| CN-102143940-A | Cyclohexyl amide derivatives as CRF-1 receptor antagonists and uses thereof | NOVARTIS AG | 2011-08-03 | — | — | CN | disclosed |