Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 19/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | CRHR2 | Q13324 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24405389 | 0.88 | CRHR1 (0.64) | CRHR1CRHR2 | |
| SCHEMBL27816992 | 0.86 | CRHR1 (0.63) | CRHR1CRHR2 | |
| SCHEMBL24405601 | 0.86 | LMNA (0.56) | NPC1RAB9A | |
| SCHEMBL24405365 | 0.86 | LMNA (0.56) | NPC1RAB9A | |
| SCHEMBL27998886 | 0.85 | CRHR1 (0.61) | CRHR1CRHR2 | |
| SCHEMBL27998885 | 0.85 | CRHR1 (0.61) | CRHR1CRHR2 | |
| SCHEMBL2317531 | 0.84 | CRHR1 (0.60) | CRHR1CRHR2 | |
| SCHEMBL30615456 | 0.84 | CRHR1 (0.70) | CRHR1CRHR2 | |
| SCHEMBL1850200 | 0.84 | CRHR1 (0.70) | CRHR1CRHR2 | |
| SCHEMBL2317525 | 0.84 | CRHR1 (0.60) | CRHR1CRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3774739-B1 | FUSED CYCLIC UREA DERIVATIVES AS CRHR2 ANTAGONIST | RAQUALIA PHARMA INC (JP) | 2022-05-11 | — | — | EP | disclosed |
| WO-2022071484-A1 | 3-HYDROXYOXINDOLE DERIVATIVES AS CRHR2 ANTAGONIST | RAQUALIA PHARMA INC. (JP) | 2022-04-07 | — | — | WO | disclosed |
| WO-2019198692-A1 | FUSED CYCLIC UREA DERIVATIVES AS CRHR2 ANTAGONIST | RAQUALIA PHARMA INC. (JP) | 2019-10-17 | — | — | WO | disclosed |