Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 1.00 |
| ▸ | NPC1 | O15118 | 5/20 | 1.00 |
| ▸ | CASP3 | P42574 | 1/20 | 0.65 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.65 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.65 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | STAT1 | P42224 | 1/20 | 0.60 |
| ▸ | GFER | P55789 | 1/20 | 0.60 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.57 |
| ▸ | EIF4E | P06730 | 6/20 | 0.54 |
| ▸ | AR | P10275 | 1/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.53 |
| ▸ | PRNP | P04156 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20333483 | 0.89 | RAB9A (0.80) | RAB9ASMN1; SMN2NPC1CASP3SENP8 | |
| SCHEMBL17336832 | 0.88 | SMN1; SMN2 (0.79) | RAB9ASMN1; SMN2NPC1CASP3SENP8 | |
| SCHEMBL27965806 | 0.88 | RAB9A (0.78) | RAB9ASMN1; SMN2NPC1CASP3SENP8 | |
| SCHEMBL5198963 | 0.87 | RAB9A (0.76) | RAB9ASMN1; SMN2NPC1CASP3SENP8 | |
| SCHEMBL23742612 | 0.86 | RAB9A (0.76) | RAB9ASMN1; SMN2NPC1CASP3SENP8 | |
| SCHEMBL2799949 | 0.84 | RAB9A (0.72) | RAB9ASMN1; SMN2NPC1CASP3SENP8 | |
| SCHEMBL14153033 | 0.83 | RAB9A (0.70) | RAB9ASMN1; SMN2NPC1CASP3SENP8 | |
| SCHEMBL11213832 | 0.83 | RAB9A (0.77) | RAB9ASMN1; SMN2NPC1CASP3SENP8 | |
| SCHEMBL14106326 | 0.81 | NPC1 (0.67) | RAB9ASMN1; SMN2NPC1KDM4EKMT2A | |
| SCHEMBL1339930 | 0.81 | RAB9A (0.68) | RAB9ASMN1; SMN2NPC1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2764052-B1 | IRON(III) CONTAINING COMPLEX AND CONDENSATION REACTION CATALYSTS, METHODS FOR PREPARING THE CATALYSTS, AND COMPOSITIONS CONTAINING THE CATALYSTS | DOW SILICONES CORP (US) | 2018-07-18 | — | — | EP | disclosed |
| US-9567325-B2 | Carboxamide compounds and their use as calpain inhibitors | AbbVie Deutschland GmbH & Co. KG (DE) | 2017-02-14 | — | — | US | disclosed |
| US-9328205-B2 | Iron(III) containing complex and condensation reaction catalysts, methods for preparing the catalysts, and compositions containing the catalysts | DOW CORNING CORPORATION (US) | 2016-05-03 | — | — | US | disclosed |
| US-9328205-B2 | Iron(III) containing complex and condensation reaction catalysts, methods for preparing the catalysts, and compositions containing the catalysts | DOW CORNING CORPORATION (US) | 2016-05-03 | — | — | US | disclosed |
| US-9328205-B2 | Iron(III) containing complex and condensation reaction catalysts, methods for preparing the catalysts, and compositions containing the catalysts | DOW CORNING CORPORATION (US) | 2016-05-03 | — | — | US | disclosed |
| US-20150045394-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-02-12 | — | — | US | disclosed |
| US-20140371056-A1 | Iron(III) Containing Complex and Condensation Reaction Catalysts, Methods for Preparing the Catalysts, and Compositions Containing the Catalysts | DOW COMING CORPORATION (US) | 2014-12-18 | — | — | US | disclosed |
| US-20140371056-A1 | Iron(III) Containing Complex and Condensation Reaction Catalysts, Methods for Preparing the Catalysts, and Compositions Containing the Catalysts | DOW COMING CORPORATION (US) | 2014-12-18 | — | — | US | disclosed |
| US-20140371056-A1 | Iron(III) Containing Complex and Condensation Reaction Catalysts, Methods for Preparing the Catalysts, and Compositions Containing the Catalysts | DOW COMING CORPORATION (US) | 2014-12-18 | — | — | US | disclosed |
| US-8906941-B2 | Carboxamide compounds and their use as calpain inhibitors | ABBVIE INC. (US) | 2014-12-09 | — | — | US | disclosed |
| EP-2764052-A2 | IRON(III) CONTAINING COMPLEX AND CONDENSATION REACTION CATALYSTS, METHODS FOR PREPARING THE CATALYSTS, AND COMPOSITIONS CONTAINING THE CATALYSTS | Dow Corning Corporation (US) | 2014-08-13 | — | — | EP | disclosed |
| CN-103842441-A | Iron(iii) containing complex and condensation reaction catalysts, methods for preparing the catalysts, and compositions containing the catalysts | DOW CORNING | 2014-06-04 | — | — | CN | disclosed |
| WO-2013052585-A2 | IRON(III) CONTAINING COMPLEX AND CONDENSATION REACTION CATALYSTS, METHODS FOR PREPARING THE CATALYSTS, AND COMPOSITIONS CONTAINING THE CATALYSTS | DOW CORNING CORPORATION (US) | 2013-04-11 | — | — | WO | disclosed |
| WO-2013052585-A2 | IRON(III) CONTAINING COMPLEX AND CONDENSATION REACTION CATALYSTS, METHODS FOR PREPARING THE CATALYSTS, AND COMPOSITIONS CONTAINING THE CATALYSTS | DOW CORNING CORPORATION (US) | 2013-04-11 | — | — | WO | disclosed |
| EP-2398783-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | Abbott GmbH & Co. KG (DE) | 2011-12-28 | — | — | EP | disclosed |
| US-20100216844-A1 | Carboxamide compounds and their use as calpain inhibitors | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2010-08-26 | — | — | US | disclosed |
| WO-2010094755-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2010-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150045394-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | CAMK4, CAMK2A, CAMK2B | RAB9A 3300/4885SMN1; SMN2 1252/4885NPC1 4325/4885 |
| US-20100216844-A1 | Carboxamide compounds and their use as calpain inhibitors | CAMK4, CAMK2A, CAMK2B | RAB9A 3299/4885SMN1; SMN2 1215/4885NPC1 4352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.