Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL501560 | 0.85 | LMNA (0.53) | LMNAL3MBTL1ABCB1SMN1; SMN2KMT2A | |
| SCHEMBL27725575 | 0.78 | HPGD (0.56) | LMNASMN1; SMN2KMT2AALDH1A1NPC1 | |
| SCHEMBL16984729 | 0.75 | AKR1C3 (0.51) | LMNAL3MBTL1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL30637700 | 0.74 | NPC1 (0.56) | LMNAL3MBTL1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL501351 | 0.74 | NPC1 (0.56) | LMNAL3MBTL1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL2223630 | 0.73 | ALDH1A1 (0.52) | LMNAABCB1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL4203673 | 0.73 | SMN1; SMN2 (0.64) | LMNAL3MBTL1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL24611945 | 0.72 | POLB (0.48) | LMNAL3MBTL1SMN1; SMN2KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL18037806 | 0.72 | KDM4E (0.46) | LMNAL3MBTL1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL16463460 | 0.72 | AURKA (0.47) | LMNAL3MBTL1SMN1; SMN2KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104411709-A | Imidazo [2,1]thiazol-3-one derivatives useful as diagnostic agents for alzheimer's disease | HOFFMANN LA ROCHE | 2015-03-11 | — | — | CN | disclosed |