Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.45 |
| ▸ | ATP4A | P20648 | 2/20 | 0.44 |
| ▸ | ATP4B | P51164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 2/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28003155 | 0.81 | SCN10A (0.49) | CYP19A1MAPTKDM4EPIM1 | |
| SCHEMBL28003513 | 0.81 | CYP19A1 (0.60) | CYP19A1MAPTCDK2KDM4EKMT2A | |
| SCHEMBL21479711 | 0.79 | KDM4E (0.68) | CYP19A1TP53MAPTATP4AATP4B | |
| SCHEMBL2307283 | 0.78 | CYP2E1 (0.47) | TP53MAPTATP4AATP4BKDM4E | |
| SCHEMBL28817509 | 0.78 | GFER (0.53) | CYP19A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL5396498 | 0.78 | RAB9A (0.50) | CYP19A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL2096509 | 0.77 | TP53 (0.52) | TP53MAPTKDM4ELMNA | |
| SCHEMBL2096508 | 0.77 | PIM1 (0.52) | TP53MAPTATP4AATP4BKDM4E | |
| SCHEMBL21479710 | 0.76 | KDM4E (0.68) | CYP19A1ATP4AATP4BKDM4EMEN1 | |
| SCHEMBL28482008 | 0.76 | TLR7 (0.46) | TP53MAPTKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104583218-A | Imidazothiadiazole and imidazopyrazine derivatives as protease activated receptor 4(PAR4) inhibitors for the treatment of platelet aggregation | BRISTOL MYERS SQUIBB CO | 2015-04-29 | — | — | CN | disclosed |