Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 5/20 | 0.62 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30259037 | 1.00 | MAPK1 (0.62) | MAPK1CHEK1JAK2BRD4 | |
| SCHEMBL31229864 | 0.85 | MAPK1 (0.49) | MAPK1CHEK1BRD4 | |
| SCHEMBL17005371 | 0.85 | MAPK1 (0.49) | MAPK1CHEK1BRD4 | |
| SCHEMBL12657766 | 0.84 | MAPK1 (0.67) | MAPK1CHEK1BRD4 | |
| SCHEMBL20846079 | 0.77 | ALDH1A1 (0.41) | MAPK1JAK2 | |
| SCHEMBL21821096 | 0.77 | MAPK1 (0.62) | MAPK1CHEK1BRD4 | |
| SCHEMBL30258999 | 0.77 | MAPK1 (0.62) | MAPK1CHEK1BRD4 | |
| SCHEMBL29488969 | 0.77 | MAPK1 (1.00) | MAPK1CHEK1JAK2BRD4 | |
| SCHEMBL649129 | 0.77 | MAPK1 (1.00) | MAPK1CHEK1JAK2BRD4 | |
| SCHEMBL14655319 | 0.72 | JAK2 (0.40) | JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108727369-B | Influenza virus replication inhibitors and uses thereof | 广东东阳光药业有限公司 | 2023-06-09 | — | — | CN | disclosed |
| EP-3555095-B1 | INHIBITORS OF INFLUENZA VIRUS REPLICATION AND USES THEREOF | SUNSHINE LAKE PHARMA CO LTD (CN) | 2023-04-12 | — | — | EP | disclosed |
| CN-110117285-B | Inhibitors of influenza virus replication and uses thereof | 广东东阳光药业有限公司 | 2023-02-03 | — | — | CN | disclosed |
| US-10987354-B2 | Inhibitors of influenza virus replication and uses thereof | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2021-04-27 | — | — | US | disclosed |
| CN-106336413-B | Compounds as JAK inhibitors and uses thereof | 广东东阳光药业有限公司 | 2021-04-20 | — | — | CN | disclosed |
| CN-108218873-B | Inhibitors of influenza virus replication and uses thereof | 广东东阳光药业有限公司 | 2020-07-07 | — | — | CN | disclosed |
| US-20200085822-A1 | INHIBITORS OF INFLUENZA VIRUS REPLICATION AND USES THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2020-03-19 | — | — | US | disclosed |
| WO-2019057660-A1 | INDOLE AND AZAINDOLE COMPOUNDS WITH SUBSTITUTED 6-MEMBERED ARYL AND HETEROARYL RINGS AS AGROCHEMICAL FUNGICIDES | BASF SE (DE) | 2019-03-28 | — | — | WO | disclosed |
| WO-2019057660-A1 | INDOLE AND AZAINDOLE COMPOUNDS WITH SUBSTITUTED 6-MEMBERED ARYL AND HETEROARYL RINGS AS AGROCHEMICAL FUNGICIDES | BASF SE (DE) | 2019-03-28 | — | — | WO | disclosed |
| EP-2858984-A1 | INHIBITORS OF INFLUENZA VIRUSES REPLICATION | Vertex Pharmaceuticals Inc. (US) | 2015-04-15 | — | — | EP | disclosed |
| WO-2009106444-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | disclosed |
| WO-2009106444-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | disclosed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | disclosed |
| US-20090215785-A1 | Pyrrolopyrazine kinase inhibitors | ROCHE PALO ALTO LLC | 2009-08-27 | — | — | US | disclosed |
| US-20090215785-A1 | Pyrrolopyrazine kinase inhibitors | ROCHE PALO ALTO LLC | 2009-08-27 | — | — | US | disclosed |
| US-20090215785-A1 | Pyrrolopyrazine kinase inhibitors | ROCHE PALO ALTO LLC | 2009-08-27 | — | — | US | disclosed |
| CN-101098872-A | Pyrrolopyrazines and pyrazolopyrazines useful as protein kinase inhibitors | VERTEX PHARMA (US) | 2008-01-02 | — | — | CN | disclosed |
| EP-1814882-A1 | PYRROLOPYRAZINES AND PYRAZOLOPYRAZINES USEFUL AS INHIBITORS OF PROTEIN KINASES | Vertex Pharmaceuticals Incorporated (US) | 2007-08-08 | — | — | EP | disclosed |
| US-20060258662-A1 | Pyrrolopyrazines and pyrazolopyrazines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2006-11-16 | — | — | US | disclosed |
| WO-2006058074-A1 | PYRROLOPYRAZINES AND PYRAZOLOPYRAZINES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-06-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10987354-B2 | Inhibitors of influenza virus replication and uses thereof | ZC3HAV1, MAVS, POLRMT | MAPK1 2020/4885CHEK1 1527/4885JAK2 1611/4885 |
| US-20090215785-A1 | Pyrrolopyrazine kinase inhibitors | SYK, ZAP70, JAK2 | MAPK1 431/4885CHEK1 1676/4885JAK2 3/4885 |
| US-20060258662-A1 | Pyrrolopyrazines and pyrazolopyrazines useful as inhibitors of protein kinases | AURKC, AURKA, PLK1 | MAPK1 390/4885CHEK1 103/4885JAK2 278/4885 |
| US-20200085822-A1 | INHIBITORS OF INFLUENZA VIRUS REPLICATION AND USES THEREOF | ZC3HAV1, MAVS, POLRMT | MAPK1 2020/4885CHEK1 1527/4885JAK2 1611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.