SCHEMBL28006147

SCHEMBL28006147

CCCc1ccc(-c2ccc(-c3ccccc3)cc2)c(C)c1C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDCD1 Q15116 3/20 0.44
CD274 Q9NZQ7 3/20 0.44
SMN1; SMN2 Q16637 3/20 0.38
MAPT P10636 3/20 0.38
HPGD P15428 2/20 0.38
PTGS1 P23219 1/20 0.38
KDM4E B2RXH2 1/20 0.38
NPC1 O15118 1/20 0.38
ALDH1A1 P00352 1/20 0.38
PKM P14618 1/20 0.38
RAB9A P51151 1/20 0.38
HSD17B10 Q99714 1/20 0.38
L3MBTL1 Q9Y468 2/20 0.36
PPARA Q07869 1/20 0.35
FFAR4 Q5NUL3 1/20 0.35
HSD11B1 P28845 2/20 0.35
ESR2 Q92731 1/20 0.34
PARP10 Q53GL7 1/20 0.34
PARP11 Q9NR21 1/20 0.34
ADORA3 P0DMS8 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9342239 0.96 PDCD1 (0.47) PDCD1CD274MAPTPTGS1PPARA
SCHEMBL28006148 0.88 PDCD1 (0.43) PDCD1CD274SMN1; SMN2MAPTPTGS1
SCHEMBL8679942 0.86 PDCD1 (0.44) PDCD1CD274PTGS1HSD11B1
SCHEMBL6546839 0.81 CD274 (0.67) PDCD1CD274PTGS1PPARADPP4
SCHEMBL8679266 0.81 CD274 (0.50) PDCD1CD274SMN1; SMN2MAPTPTGS1
SCHEMBL11200440 0.80 PDCD1 (0.46) PDCD1CD274PTGS1NPC1RAB9A
SCHEMBL5595171 0.78 SMN1; SMN2 (0.40) SMN1; SMN2MAPTHPGDPTGS1KDM4E
SCHEMBL10798309 0.78 SMN1; SMN2 (0.40) SMN1; SMN2MAPTHPGDPTGS1KDM4E
SCHEMBL10798302 0.77 DPP4 (0.52) PDCD1CD274SMN1; SMN2MAPTHPGD
SCHEMBL5153010 0.76 FFAR4 (0.53) PDCD1CD274SMN1; SMN2MAPTPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101687403-B Transparent hard coat film, antireflection film using the same, polarizing plate, and display device KONICA MINOLTA OPTO INC 2015-04-01 CN disclosed