Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL311206 | 0.86 | TDP1 (0.69) | TDP1L3MBTL1MAPTGAASMN1; SMN2 | |
| SCHEMBL28005008 | 0.83 | TDP1 (0.53) | TDP1L3MBTL1MAPTGAASMN1; SMN2 | |
| SCHEMBL28027851 | 0.83 | TDP1 (0.53) | TDP1L3MBTL1MAPTGAASMN1; SMN2 | |
| SCHEMBL949562 | 0.82 | TDP1 (0.50) | TDP1L3MBTL1MAPTGAASMN1; SMN2 | |
| SCHEMBL30592857 | 0.80 | TDP1 (0.57) | TDP1L3MBTL1MAPTGAASMN1; SMN2 | |
| SCHEMBL31081770 | 0.80 | TDP1 (0.49) | TDP1L3MBTL1MAPTGAASMN1; SMN2 | |
| SCHEMBL18201 | 0.80 | TDP1 (0.57) | TDP1L3MBTL1MAPTGAASMN1; SMN2 | |
| SCHEMBL8427582 | 0.80 | TDP1 (0.49) | TDP1L3MBTL1MAPTGAASMN1; SMN2 | |
| SCHEMBL9944383 | 0.80 | MAPT (0.51) | TDP1L3MBTL1MAPTGAASMN1; SMN2 | |
| SCHEMBL311599 | 0.80 | L3MBTL1 (0.59) | L3MBTL1MAPTSMN1; SMN2ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104507940-A | Heterocyclic compounds | TAKEDA PHARMACEUTICAL | 2015-04-08 | — | — | CN | disclosed |