SCHEMBL28007255

SCHEMBL28007255

Cc1c(I)ccc(C(=O)O)c1C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.44
TSHR P16473 1/20 0.40
HAAO P46952 1/20 0.39
GABRP O00591 1/20 0.39
GABRD O14764 1/20 0.39
GABRA1 P14867 1/20 0.39
GABRB1 P18505 1/20 0.39
GABRG2 P18507 1/20 0.39
GABRB3 P28472 1/20 0.39
GABRA5 P31644 1/20 0.39
GABRA3 P34903 1/20 0.39
GABRA2 P47869 1/20 0.39
GABRB2 P47870 1/20 0.39
GABRA4 P48169 1/20 0.39
GABRE P78334 1/20 0.39
GABRA6 Q16445 1/20 0.39
GABRG1 Q8N1C3 1/20 0.39
GABRG3 Q99928 1/20 0.39
GABRQ Q9UN88 1/20 0.39
ALDH1A1 P00352 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31389208 0.85 CYP1A2 (0.58) CYP1A2TSHRHAAOGABRPGABRD
SCHEMBL128319 0.85 CYP1A2 (0.58) CYP1A2TSHRHAAOGABRPGABRD
Ammonia Solution, Strong SCHEMBL29137499 0.83 CYP1A2 (0.55) CYP1A2TSHRHAAOGABRPGABRD
SCHEMBL2085354 0.83 ALDH1A1 (0.44) CYP1A2TSHRHAAOGABRPGABRD
SCHEMBL27289184 0.83 CYP1A2 (0.41) CYP1A2TSHRHAAOGABRPGABRD
SCHEMBL6155380 0.83 GRM1 (0.51) CYP1A2TSHRHAAOGABRPGABRD
SCHEMBL5737114 0.81 KDM4E (0.40) CYP1A2HAAOGABRPGABRDGABRA1
SCHEMBL148622 0.81 GABRP (0.44) CYP1A2TSHRHAAOGABRPGABRD
SCHEMBL10914869 0.81 GABRP (0.44) CYP1A2HAAOGABRPGABRDGABRA1
SCHEMBL28598130 0.81 CYP1A2 (0.39) CYP1A2TSHRHAAOGABRPGABRD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115260096-B Method for synthesizing dihydroisoquinolinones based on carbon monoxide gas or carbon monoxide substitution source 武汉大学 2024-04-09 CN disclosed
CN-104507928-A Heterocyclic modulators of lipid synthesis 3 V BIOSCIENCES INC 2015-04-08 CN disclosed