Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1902358 | 0.89 | SMN1; SMN2 (0.76) | SMN1; SMN2HTTALDH1A1HPGDTSHR | |
| SCHEMBL10255967 | 0.86 | ALDH1A1 (0.67) | SMN1; SMN2HTTALDH1A1HPGDTSHR | |
| SCHEMBL2525981 | 0.86 | ALDH1A1 (0.60) | SMN1; SMN2HTTALDH1A1HPGDTSHR | |
| SCHEMBL20875889 | 0.86 | ALDH1A1 (0.60) | SMN1; SMN2HTTALDH1A1HPGDTSHR | |
| SCHEMBL9144175 | 0.86 | ALDH1A1 (0.67) | SMN1; SMN2HTTALDH1A1HPGDTSHR | |
| SCHEMBL27412659 | 0.85 | ALDH1A1 (0.79) | SMN1; SMN2HTTALDH1A1MAPT | |
| SCHEMBL9437311 | 0.84 | ALDH1A1 (0.60) | SMN1; SMN2HTTALDH1A1HPGDTSHR | |
| SCHEMBL9437361 | 0.82 | L3MBTL1 (0.64) | SMN1; SMN2HTTALDH1A1LMNANPC1 | |
| SCHEMBL14966487 | 0.82 | ALDH1A1 (0.66) | SMN1; SMN2HTTALDH1A1LMNANPC1 | |
| SCHEMBL5970008 | 0.82 | ALDH1A1 (0.62) | SMN1; SMN2HTTALDH1A1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104447733-B | 1-benzyl-2-pyrrolinone-4-amides compound and preparation method and application | 中国药科大学 | 2016-08-17 | — | — | CN | claimed |
| CN-104447733-A | 1-benzyl-2-pyrroline ketone-4-amide compounds and preparing method and application thereof | UNIV CHINA PHARMA | 2015-03-25 | — | — | CN | claimed |
| CN-104447733-B | 1-benzyl-2-pyrrolinone-4-amides compound and preparation method and application | 中国药科大学 | 2016-08-17 | — | — | CN | disclosed |
| CN-104447733-A | 1-benzyl-2-pyrroline ketone-4-amide compounds and preparing method and application thereof | UNIV CHINA PHARMA | 2015-03-25 | — | — | CN | disclosed |