Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.41 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.41 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8011431 | 0.81 | MAPT (0.45) | CYP2C19KMT2AMEN1GABBR2GABBR1 | |
| SCHEMBL27663392 | 0.81 | MAPT (0.45) | CYP2C19KMT2AMEN1GABBR2GABBR1 | |
| SCHEMBL27773550 | 0.81 | GABBR2 (0.42) | CYP2C19KMT2ACYP2D6GABBR2GABBR1 | |
| SCHEMBL1624875 | 0.80 | DPP4 (0.48) | KMT2ACYP2D6MEN1MAPTAAK1 | |
| SCHEMBL28008180 | 0.79 | MEN1 (0.47) | CYP2C19KMT2ACYP2D6MEN1CYP2C9 | |
| SCHEMBL497730 | 0.77 | CYP2C19 (0.72) | CYP2C19KMT2ACYP2D6MEN1CYP2C9 | |
| SCHEMBL497729 | 0.77 | CYP2C19 (0.72) | CYP2C19KMT2ACYP2D6MEN1CYP2C9 | |
| SCHEMBL1919826 | 0.77 | CYP2D6 (0.50) | CYP2C19KMT2ACYP2D6MEN1CYP2C9 | |
| SCHEMBL10683915 | 0.77 | MMP8 (0.39) | KMT2ACYP2D6AAK1SLC7A5CTSS | |
| SCHEMBL28750863 | 0.77 | AAK1 (0.39) | KMT2ACYP2D6MEN1MAPTAAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104662015-B | Complement pathway modulators and uses thereof | 诺华股份有限公司 | 2017-03-29 | — | — | CN | disclosed |
| CN-104662015-A | Complement pathway modulators and uses thereof | NOVARTIS AG | 2015-05-27 | — | — | CN | disclosed |