Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 6/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | VDR | P11473 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9934821 | 0.87 | APP (0.37) | APPTSHRMAPK1VDR | |
| SCHEMBL28008558 | 0.86 | TSHR (0.48) | TSHRMAPK1VDRKMT2ASMN1; SMN2 | |
| SCHEMBL27913748 | 0.81 | MGLL (0.32) | — | |
| SCHEMBL9934640 | 0.78 | APP (0.40) | APPTSHRMAPK1VDRKMT2A | |
| SCHEMBL9934322 | 0.73 | TSHR (0.50) | TSHRMAPK1VDRKMT2ASMN1; SMN2 | |
| SCHEMBL28008146 | 0.73 | TDP1 (0.35) | MAPK1 | |
| SCHEMBL28008161 | 0.73 | TDP1 (0.35) | MAPK1 | |
| SCHEMBL28008213 | 0.73 | TDP1 (0.35) | MAPK1 | |
| SCHEMBL28051634 | 0.72 | FYN (0.32) | — | |
| SCHEMBL27999329 | 0.72 | MAPT (0.39) | TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105153146-A | Novel 3-hydroxyisothiazole 1-oxide derivative | MOCHIDA PHARM CO LTD | 2015-12-16 | — | — | CN | disclosed |
| CN-103517898-B | Novel 3-hydroxyisothiazole 1-oxide derivatives | MOCHIDA PHARMACEUTICAL CO.,LTD. (JP) | 2015-09-30 | — | — | CN | disclosed |
| CN-104710381-A | Novel 3-hydroxy-5-arylisothiazole derivative | MOCHIDA PHARM CO LTD | 2015-06-17 | — | — | CN | disclosed |
| CN-102712610-B | Novel 3-hydroxy-5-arylisothiazole derivatives | MOCHIDA PHARM CO LTD | 2015-03-04 | — | — | CN | disclosed |