SCHEMBL28008282

SCHEMBL28008282

CCOC(=O)C#Cc1ccccc1C(C)(C)C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NLRP3 Q96P20 2/20 0.39
TSHR P16473 2/20 0.39
ALDH1A1 P00352 6/20 0.37
GAA P10253 3/20 0.37
L3MBTL1 Q9Y468 2/20 0.37
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
NPC1 O15118 2/20 0.36
PIN1 Q13526 1/20 0.36
NAMPT P43490 1/20 0.35
MMP8 P22894 1/20 0.35
KDM4E B2RXH2 3/20 0.35
TDP1 Q9NUW8 2/20 0.35
HPGD P15428 2/20 0.35
HSD17B10 Q99714 1/20 0.34
HDAC3 O15379 1/20 0.34
HDAC4 P56524 1/20 0.34
HDAC1 Q13547 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34
TP53 P04637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1625654 0.83 ALDH1A1 (0.37) NLRP3TSHRALDH1A1GAAL3MBTL1
SCHEMBL9372996 0.81 FFAR1 (0.47) NLRP3TSHRALDH1A1GAAL3MBTL1
SCHEMBL28008689 0.80 FFAR1 (0.44) NLRP3TSHRALDH1A1GAAL3MBTL1
SCHEMBL6774626 0.78 GRM5 (0.46) NLRP3TSHRALDH1A1GAAL3MBTL1
SCHEMBL4637931 0.78 PTGDR2 (0.47) NLRP3TSHRALDH1A1GAAL3MBTL1
SCHEMBL852401 0.77 FFAR1 (0.47) TSHRALDH1A1GAAL3MBTL1MEN1
SCHEMBL16713296 0.77 L3MBTL1 (0.46) TSHRALDH1A1GAAL3MBTL1MEN1
SCHEMBL852937 0.76 ALDH1A1 (0.49) TSHRALDH1A1GAAL3MBTL1KMT2A
SCHEMBL16673211 0.75 FFAR1 (0.49) TSHRALDH1A1GAAL3MBTL1HSD17B10
SCHEMBL852513 0.74 GAA (0.50) NLRP3TSHRGAAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104412441-A Nonaqueous electrolyte solution and nonaqueous electrolyte battery using same MITSUBISHI CHEM CORP 2015-03-11 CN disclosed