Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | CFD | P00746 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20993600 | 1.00 | HTT (0.54) | HTTMAPTALDH1A1CYP2D6KCNH2 | |
| SCHEMBL16679992 | 0.84 | FFAR1 (0.47) | ALDH1A1LMNAHPGDGAANPSR1 | |
| SCHEMBL13802626 | 0.84 | KCNA5 (0.47) | ALDH1A1LMNAHPGDROCK2MEN1 | |
| SCHEMBL16679989 | 0.84 | FFAR1 (0.47) | ALDH1A1LMNAHPGDGAANPSR1 | |
| SCHEMBL16680217 | 0.84 | ALDH1A1 (0.50) | HTTMAPTALDH1A1CYP2D6KCNH2 | |
| SCHEMBL16680215 | 0.84 | ALDH1A1 (0.50) | HTTMAPTALDH1A1CYP2D6KCNH2 | |
| SCHEMBL29288506 | 0.83 | FFAR1 (0.46) | ALDH1A1LMNAHPGDGAANPSR1 | |
| SCHEMBL29288504 | 0.83 | FFAR1 (0.46) | ALDH1A1LMNAHPGDGAANPSR1 | |
| SCHEMBL22024055 | 0.81 | HPGD (0.43) | HTTMAPTALDH1A1CYP2D6KCNH2 | |
| SCHEMBL4855579 | 0.81 | ALDH1A1 (0.48) | HTTMAPTALDH1A1CYP2D6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104662015-B | Complement pathway modulators and uses thereof | 诺华股份有限公司 | 2017-03-29 | — | — | CN | disclosed |
| CN-104662015-A | Complement pathway modulators and uses thereof | NOVARTIS AG | 2015-05-27 | — | — | CN | disclosed |