Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 2/20 | 0.55 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.55 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.55 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | TPH1 | P17752 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6367462 | 0.73 | CASP3 (0.60) | CASP3SENP8SENP7SENP6TPH1 | |
| SCHEMBL4798828 | 0.72 | TPH1 (0.50) | CASP3SENP8SENP7SENP6TPH1 | |
| SCHEMBL11711449 | 0.71 | TPH1 (0.56) | TPH1HDAC1HDAC8HDAC2MAPT | |
| SCHEMBL1505380 | 0.70 | TPH1 (0.61) | TPH1HDAC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8163626 | 0.70 | TPH1 (0.61) | TPH1HDAC1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL24989003 | 0.70 | HDAC4 (0.50) | TPH1HDAC1HDAC8HDAC2NPC1 | |
| SCHEMBL28816242 | 0.69 | KMT2A (0.53) | CASP3SENP8SENP7SENP6TPH1 | |
| SCHEMBL27683231 | 0.69 | BCL2L1 (0.62) | TPH1HDAC1MAPTNPC1RAB9A | |
| SCHEMBL14814209 | 0.68 | KMT2A (0.49) | CASP3SENP8SENP7TPH1HDAC1 | |
| SCHEMBL4127648 | 0.68 | KMT2A (0.46) | CASP3SENP8SENP7TPH1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102369200-B | Derivatives of azaspiranyl-alkylcarbamates of 5-member heterocyclic compounds, preparation thereof and therapeutic use thereof | SANOFI SA | 2015-05-20 | — | — | CN | disclosed |