SCHEMBL28009145

SCHEMBL28009145

Brc1ccc2c(c1)c1cc(-c3ccccc3)ccc1n2-c1ccccn1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 5/20 0.43
KMT2A Q03164 5/20 0.43
NPSR1 Q6W5P4 2/20 0.43
ALDH1A1 P00352 4/20 0.39
MAPK1 P28482 3/20 0.39
MAPT P10636 2/20 0.39
KDM4E B2RXH2 2/20 0.39
LMNA P02545 2/20 0.39
HTT P42858 1/20 0.39
UHRF1 Q96T88 1/20 0.39
PLAUR Q03405 1/20 0.39
IRAK4 Q9NWZ3 2/20 0.39
DCLK1 O15075 1/20 0.39
PRKD3 O94806 1/20 0.39
MAP4K4 O95819 1/20 0.39
CHEK2 O96017 1/20 0.39
CSF1R P07333 1/20 0.39
FER P16591 1/20 0.39
CDK2 P24941 1/20 0.39
MARK3 P27448 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28728317 0.90 MEN1 (0.43) MEN1KMT2ANPSR1ALDH1A1MAPT
SCHEMBL19533807 0.89 MEN1 (0.48) MEN1KMT2ANPSR1ALDH1A1MAPK1
SCHEMBL28009140 0.88 MEN1 (0.42) MEN1KMT2ANPSR1ALDH1A1MAPT
SCHEMBL2730486 0.85 MEN1 (0.43) MEN1KMT2ANPSR1ALDH1A1MAPK1
SCHEMBL29853603 0.85 MEN1 (0.43) MEN1KMT2ANPSR1ALDH1A1MAPK1
SCHEMBL30118206 0.84 ALDH1A1 (0.40) MEN1KMT2AALDH1A1MAPK1MAPT
SCHEMBL17228138 0.84 ALDH1A1 (0.41) MEN1KMT2ANPSR1ALDH1A1MAPK1
SCHEMBL21069154 0.83 ALDH1A1 (0.40) MEN1KMT2AALDH1A1MAPK1MAPT
SCHEMBL20391831 0.82 KDM4E (0.45) MEN1KMT2ANPSR1ALDH1A1MAPK1
SCHEMBL24137222 0.82 ALDH1A1 (0.42) MEN1KMT2ANPSR1ALDH1A1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104507927-A Cyclic azine compound, method for producing same, and organic electroluminescent element containing same TOSOH CORP 2015-04-08 CN disclosed