Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 4/20 | 0.56 |
| ▸ | CMA1 | P23946 | 2/20 | 0.56 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.54 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | TDP2 | O95551 | 1/20 | 0.48 |
| ▸ | HTR5A | P47898 | 2/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.43 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30648196 | 0.94 | AHR (0.61) | AHRCMA1EIF2AK2PDK2TDP2 | |
| SCHEMBL260027 | 0.94 | AHR (0.61) | AHRCMA1EIF2AK2PDK2TDP2 | |
| SCHEMBL7717893 | 0.93 | AHR (0.59) | AHRCMA1EIF2AK2PDK2TDP2 | |
| SCHEMBL5843103 | 0.82 | CRBN (0.57) | AHRCMA1EIF2AK2PDK2TDP2 | |
| Methylamine SCHEMBL28015139 | 0.80 | CA9 (0.66) | AHRCMA1EIF2AK2PDK2TDP2 | |
| SCHEMBL152963 | 0.79 | AHR (0.61) | AHRCMA1PDK2TDP2HTR5A | |
| Methylamine SCHEMBL27858404 | 0.79 | AHR (0.89) | AHRCMA1EIF2AK2PDK2TDP2 | |
| SCHEMBL29754281 | 0.78 | CA9 (0.62) | HTR5ACRBNMAOBCA9 | |
| SCHEMBL4102521 | 0.78 | CA9 (0.62) | HTR5ACRBNMAOBCA9 | |
| SCHEMBL7505614 | 0.76 | MAPT (0.59) | AHRCMA1HTR5ACRBNCA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104619701-A | 2-oxo-2,3-dihydro-indoles for the treatment of cns disorders | HOFFMANN LA ROCHE | 2015-05-13 | — | — | CN | disclosed |