Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.55 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.55 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 5/20 | 0.48 |
| ▸ | MAOA | P21397 | 4/20 | 0.48 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTR5A | P47898 | 2/20 | 0.46 |
| ▸ | KIF11 | P52732 | 1/20 | 0.45 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4102521 | 1.00 | CA9 (0.62) | CA9KMT2AKDM4ELMNASMN1; SMN2 | |
| SCHEMBL7505614 | 0.91 | MAPT (0.59) | CA9KMT2AKDM4ELMNASMN1; SMN2 | |
| SCHEMBL2233596 | 0.85 | PKM (0.58) | CA9KMT2AKDM4ELMNASMN1; SMN2 | |
| SCHEMBL260027 | 0.82 | AHR (0.61) | KMT2AKDM4ELMNASMN1; SMN2SRD5A1 | |
| SCHEMBL30648196 | 0.82 | AHR (0.61) | KMT2AKDM4ELMNASMN1; SMN2SRD5A1 | |
| SCHEMBL7717893 | 0.81 | AHR (0.59) | KMT2AKDM4ELMNASMN1; SMN2SRD5A1 | |
| SCHEMBL3308993 | 0.80 | CA9 (0.53) | CA9KMT2AKDM4ELMNASMN1; SMN2 | |
| SCHEMBL31310681 | 0.78 | MAPT (0.58) | KMT2ASRD5A1NPC1MAPK13MAPK12 | |
| SCHEMBL8031052 | 0.78 | HTR5A (0.44) | CA9KMT2AKDM4ELMNASMN1; SMN2 | |
| SCHEMBL31310679 | 0.78 | MAPT (0.58) | KMT2ASRD5A1NPC1MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112638881-B | Tetrahydroquinoline derivatives for the treatment of metastatic and chemotherapy-resistant cancers | 普林斯顿大学托管委员会 | 2025-01-07 | — | — | CN | disclosed |
| CN-114436955-B | Tetrahydroquinoline and benzomorpholine derivatives or salts thereof, and preparation method and application thereof | 复旦大学 | 2024-08-09 | — | — | CN | disclosed |
| CN-118324767-A | Diacylglycerol kinase modulating compounds | 卡尔那生物科学株式会社 | 2024-07-12 | — | — | CN | disclosed |
| EP-4093400-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | The Trustees of Princeton University (US) | 2022-11-30 | — | — | EP | disclosed |
| CN-115362003-A | Diacylglycerol kinase modulating compounds | 卡尔那生物科学株式会社 | 2022-11-18 | — | — | CN | disclosed |
| CN-114436955-A | Tetrahydroquinoline and benzomorpholine derivatives or salts thereof, and preparation method and application thereof | 复旦大学 | 2022-05-06 | — | — | CN | disclosed |