Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 4/20 | 0.59 |
| ▸ | CMA1 | P23946 | 2/20 | 0.59 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.58 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.52 |
| ▸ | TDP2 | O95551 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | HTR5A | P47898 | 2/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL260027 | 0.98 | AHR (0.61) | AHRCMA1EIF2AK2PDK2TDP2 | |
| SCHEMBL30648196 | 0.98 | AHR (0.61) | AHRCMA1EIF2AK2PDK2TDP2 | |
| Methylamine SCHEMBL28014455 | 0.93 | AHR (0.56) | AHRCMA1EIF2AK2PDK2TDP2 | |
| SCHEMBL5843103 | 0.85 | CRBN (0.57) | AHRCMA1EIF2AK2PDK2TDP2 | |
| SCHEMBL152963 | 0.82 | AHR (0.61) | AHRCMA1PDK2TDP2MAOB | |
| SCHEMBL29754281 | 0.81 | CA9 (0.62) | MAOBHTR5ACRBNSRD5A1KMT2A | |
| SCHEMBL4102521 | 0.81 | CA9 (0.62) | MAOBHTR5ACRBNSRD5A1KMT2A | |
| SCHEMBL7505614 | 0.79 | MAPT (0.59) | AHRCMA1HTR5ACRBNSRD5A1 | |
| SCHEMBL8031052 | 0.78 | HTR5A (0.44) | AHRCMA1EIF2AK2TDP2HTR5A | |
| SCHEMBL4413360 | 0.76 | CCNB2 (0.54) | AHRCMA1EIF2AK2PDK2TDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1233943-A2 | IONIZABLE INDOLINONE DERIVATIVES AND THEIR USE AS PTK LIGANDS | Sugen, Inc. (US) | 2002-08-28 | — | — | EP | disclosed |
| WO-2001037820-A2 | IONIZABLE INDOLINONE DERIVATIVES AND THEIR USE AS PTK LIGANDS | SUGEN, INC. (US) | 2001-05-31 | — | — | WO | disclosed |
| EP-0984930-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Sugen, Inc. (US) | 2000-03-15 | — | — | EP | disclosed |
| WO-1998050356-A1 | 2-INDOLINONE DERIVATIVES AS MODULATORS OF PROTEIN KINASE ACTIVITY | SUGEN, INC. (US) | 1998-11-12 | — | — | WO | disclosed |