Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Oxiracetam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.87 |
| ▸ | BLM | P54132 | 1/20 | 0.87 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | FPR1 | P21462 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxiracetam SCHEMBL2596758 | 0.93 | APEX1 (1.00) | APEX1BLMTSHRSIGMAR1FPR1 | |
| Oxiracetam SCHEMBL15789330 | 0.93 | APEX1 (1.00) | APEX1BLMTSHRSIGMAR1FPR1 | |
| Oxiracetam SCHEMBL526050 | 0.93 | APEX1 (1.00) | APEX1BLMTSHRSIGMAR1FPR1 | |
| Oxiracetam SCHEMBL28956553 | 0.91 | APEX1 (0.96) | APEX1BLMTSHRSIGMAR1FPR1 | |
| Oxiracetam SCHEMBL28342561 | 0.91 | APEX1 (0.96) | APEX1BLMTSHRSIGMAR1FPR1 | |
| Oxiracetam SCHEMBL27586048 | 0.91 | APEX1 (0.96) | APEX1BLMTSHRSIGMAR1FPR1 | |
| Oxiracetam SCHEMBL15789157 | 0.91 | APEX1 (0.96) | APEX1BLMTSHRSIGMAR1FPR1 | |
| Oxiracetam SCHEMBL2322773 | 0.85 | APEX1 (0.84) | APEX1BLMTSHRSIGMAR1FPR1 | |
| SCHEMBL14426907 | 0.79 | APEX1 (0.68) | APEX1BLMPOLBBRD4TP53 | |
| Etiracetam SCHEMBL8448259 | 0.78 | LMNA (0.65) | APEX1BLMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104739760-B | A kind of pharmaceutical composition and its preparation for treating encephaledema | 山东罗欣药业集团股份有限公司 | 2018-03-06 | — | — | CN | disclosed |
| CN-107510665-A | Good levo-oxiracetam particle of a kind of content uniformity and preparation method thereof | 重庆润泽医药有限公司 | 2017-12-26 | — | — | CN | disclosed |
| CN-104739760-A | Pharmaceutical composition for treating encephaledema and preparation of pharmaceutical composition | SHANDONG LUOXIN PHARMACEUTICAL GROUP CO LTD | 2015-07-01 | — | — | CN | disclosed |