Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21694516 | 0.88 | CTSK (0.45) | SYKCTSKALDH1A1CYP3A4TSHR | |
| SCHEMBL852279 | 0.86 | SYK (0.43) | SYKCTSKALDH1A1CYP3A4TSHR | |
| SCHEMBL852280 | 0.86 | SYK (0.43) | SYKCTSKALDH1A1CYP3A4TSHR | |
| SCHEMBL27816818 | 0.84 | CTSK (0.43) | SYKCTSKALDH1A1CYP3A4TSHR | |
| SCHEMBL7376515 | 0.84 | CETP (0.44) | SYKALDH1A1CYP3A4TSHRMAPK1 | |
| SCHEMBL21694488 | 0.84 | SYK (0.44) | SYKCTSKALDH1A1CYP3A4TSHR | |
| SCHEMBL29035390 | 0.84 | SYK (0.44) | SYKCTSKALDH1A1CYP3A4TSHR | |
| SCHEMBL7298091 | 0.84 | CETP (0.44) | SYKALDH1A1CYP3A4TSHRMAPK1 | |
| SCHEMBL7295803 | 0.84 | CETP (0.44) | SYKALDH1A1CYP3A4TSHRMAPK1 | |
| SCHEMBL7419491 | 0.83 | SYK (0.52) | SYKCTSKALDH1A1MAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102471314-B | Spiro amino compounds suitable for the treatment of inter alia sleep disorders and drug addiction | ROTTAPHARM SPA | 2015-05-13 | — | — | CN | disclosed |