Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | TOP1 | P11387 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.34 |
| ▸ | KLK7 | P49862 | 1/20 | 0.34 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL852280 | 1.00 | SYK (0.43) | SYKPOLBLTA4HMAPTALDH1A1 | |
| SCHEMBL28014675 | 0.86 | SYK (0.47) | SYKPOLBLTA4HMAPTALDH1A1 | |
| SCHEMBL28616879 | 0.78 | ALDH1A1 (0.42) | SYKALDH1A1L3MBTL1CYP3A4TSHR | |
| SCHEMBL7419487 | 0.77 | SYK (0.52) | SYKPOLBLTA4HALDH1A1L3MBTL1 | |
| SCHEMBL7419491 | 0.77 | SYK (0.52) | SYKPOLBLTA4HALDH1A1L3MBTL1 | |
| SCHEMBL15626653 | 0.77 | AAK1 (0.50) | SYKPOLBLTA4HMAPTALDH1A1 | |
| SCHEMBL12690327 | 0.75 | AAK1 (0.53) | SYKPOLBLTA4HMAPTALDH1A1 | |
| SCHEMBL21694516 | 0.75 | CTSK (0.45) | SYKPOLBLTA4HMAPTALDH1A1 | |
| SCHEMBL16814420 | 0.74 | AAK1 (0.47) | SYKPOLBLTA4HMAPTALDH1A1 | |
| SCHEMBL7465906 | 0.74 | POLB (0.44) | SYKPOLBLTA4HMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1441720-B8 | INHIBITORS OF SERINE PROTEASE, PARTICULARLY HEPATITIS C VIRUS NS3-NS4A PROTEASE, INCORPORATING A FUSED RING SYSTEM | VERTEX PHARMA (US) | 2012-03-28 | — | — | EP | disclosed |