Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 6/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 6/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15015925 | 0.93 | CA2 (0.46) | CA2MAPK1CA1MEN1GAA | |
| SCHEMBL15015590 | 0.86 | KMT2A (0.41) | CA2MAPK1CA1MEN1GAA | |
| SCHEMBL28808711 | 0.85 | CA2 (0.54) | CA2MAPK1CA1MEN1GAA | |
| SCHEMBL27816815 | 0.85 | CA2 (0.42) | CA2MAPK1CA1MEN1GAA | |
| SCHEMBL28777367 | 0.83 | CA2 (0.43) | CA2MAPK1CA1MEN1GAA | |
| SCHEMBL15348701 | 0.83 | CA2 (0.43) | CA2MAPK1CA1MEN1GAA | |
| SCHEMBL15015760 | 0.82 | CHRM1 (0.40) | CA2MAPK1CA1MEN1GAA | |
| SCHEMBL13892363 | 0.82 | KMT2A (0.38) | CA2CA1MEN1GAAKMT2A | |
| SCHEMBL28795933 | 0.81 | CTSK (0.44) | CA2MAPK1CA1CTSKCTSS | |
| SCHEMBL1365236 | 0.80 | CA2 (0.58) | CA2MAPK1CA1SLC1A3SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102471314-B | Spiro amino compounds suitable for the treatment of inter alia sleep disorders and drug addiction | ROTTAPHARM SPA | 2015-05-13 | — | — | CN | disclosed |