Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | PREP | P48147 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28094324 | 0.88 | POLB (0.50) | POLBCES2CES1RAB9AKMT2A | |
| SCHEMBL27757319 | 0.82 | CA12 (0.52) | POLBCES2CES1RAB9AKMT2A | |
| SCHEMBL1489210 | 0.80 | CA12 (0.52) | POLBCES2CES1CRBNRAB9A | |
| SCHEMBL28259615 | 0.77 | POLB (0.42) | POLBCES2CES1RAB9AALDH1A1 | |
| SCHEMBL6989228 | 0.74 | CES2 (0.46) | POLBCES2CES1CRBNRAB9A | |
| SCHEMBL28350547 | 0.74 | NPC1 (0.43) | POLBRAB9AALDH1A1KMT2AMEN1 | |
| SCHEMBL10441887 | 0.73 | CES2 (0.64) | POLBCES2CES1RAB9AKMT2A | |
| SCHEMBL14454258 | 0.73 | CES2 (0.52) | POLBCES2CES1CRBNHDAC1 | |
| SCHEMBL4089662 | 0.73 | CES2 (0.52) | CES2CES1CRBNALDH1A1HDAC1 | |
| SCHEMBL6989232 | 0.73 | CES2 (0.40) | POLBCES2CES1CRBNRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104619694-A | Azetidine and piperidine compounds useful as PDE10 inhibitors | AMGEN INC | 2015-05-13 | — | — | CN | disclosed |