Sugi Predict

Sugi Predict / Compounds / SCHEMBL1489210

SCHEMBL1489210

SCHEMBL1489210

COC(=O)c1c(N)cccc1F

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA12 O43570 1/20 0.52
▸ CA1 P00915 1/20 0.52
▸ CA2 P00918 1/20 0.52
▸ CA7 P43166 1/20 0.52
▸ CA9 Q16790 1/20 0.52
▸ CA14 Q9ULX7 1/20 0.52
▸ ALDH1A1 P00352 3/20 0.52
▸ CFTR P13569 1/20 0.52
▸ HSD17B10 Q99714 1/20 0.52
▸ CES2 O00748 1/20 0.47
▸ CES1 P23141 1/20 0.47
▸ JAK1 P23458 1/20 0.44
▸ TYK2 P29597 1/20 0.44
▸ BDKRB1 P46663 2/20 0.44
▸ RAB9A P51151 1/20 0.43
▸ KMT2A Q03164 6/20 0.42
▸ IKBKB O14920 1/20 0.42
▸ POLB P06746 1/20 0.42
▸ CRBN Q96SW2 1/20 0.42
▸ LMNA P02545 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6312035 0.86 CA12 (0.61) CA12CA1CA2CA7CA9
SCHEMBL1070351 0.86 CA12 (0.61) CA12CA1CA2CA7CA9
SCHEMBL10982569 0.81 GRM6 (0.43) CA12CA1CA2CA9CA14
SCHEMBL26632163 0.80 CA12 (0.43) CA12CA1CA2CA7CA9
SCHEMBL6989228 0.80 CES2 (0.46) ALDH1A1CFTRHSD17B10CES2CES1
SCHEMBL28015207 0.80 POLB (0.44) ALDH1A1CFTRHSD17B10CES2CES1
SCHEMBL619907 0.79 CA12 (0.77) CA12CA1CA2CA7CA9
SCHEMBL436713 0.79 CA12 (0.77) CA12CA1CA2CA7CA9
SCHEMBL8056782 0.79 CA12 (0.53) CA12CA1CA2CA7CA9
SCHEMBL543900 0.79 CA12 (0.53) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 146 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12570655-B2 Cysteine covalent modifiers of AKT1 and uses thereof TERREMOTO BIOSCIENCES, INC. (US) 2026-03-10 — — US disclosed
WO-2025081045-A9 CYSTEINE COVALENT MODIFIERS OF AKT1 AND USES THEREOF TERREMOTO BIOSCIENCES, INC. (US) 2025-12-26 — — WO disclosed
US-20250289819-A1 CYSTEINE COVALENT MODIFIERS OF AKT1 AND USES THEREOF TERREMOTO BIOSCIENCES, INC. 2025-09-18 — — US disclosed
CN-120152713-A Tricyclic aryl derivatives and compositions and methods thereof 昂胜医疗科技公司 2025-06-13 — — CN disclosed
CN-120117999-A Fluorotranilast derivatives and medical application thereof 中国药科大学 2025-06-10 — — CN disclosed
EP-4561562-A2 TRICYCLIC ARYL DERIVATIVES, AND COMPOSITIONS AND METHODS THEREOF Ensem Therapeutics, Inc. (US) 2025-06-04 — — EP disclosed
WO-2025081045-A1 CYSTEINE COVALENT MODIFIERS OF AKT1 AND USES THEREOF TERREMOTO BIOSCIENCES, INC. (US) 2025-04-17 — — WO disclosed
US-20250011289-A1 1H-BENZO[B]AZEPIN-2(3H)-ONE COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING CANCER J. MICHAEL BISHOP INSTITUTE OF CANCER RESEARCH (CN) 2025-01-09 — — US disclosed
CN-115850193-B Preparation method of quinazolinone derivative 中国医学科学院阜外医院深圳医院(深圳市孙逸仙心血管医院) 2024-11-01 — — CN disclosed
CN-118525007-A 1H-benzo [ B ] azepin-2 (3H) -one compounds, compositions and methods for treating cancer 成都安泰康赛生物科技有限公司 2024-08-20 — — CN disclosed
US-5104441-A HERBICIDAL SULFONAMIDES AND THEIR USE TO INFLUENCE PLANT GROWTH BASF AKTIENGESELLSCHAFT (DE) 1992-04-14 — — US disclosed
EP-0147211-B1 4H-3,1-BENZOXAZIN-4-ONES AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND PROCESSES FOR THEIR PREPARATION SYNTEX (U.S.A.) INC. (US) 1990-09-12 — — EP disclosed
EP-0378092-A1 Herbicidal sulfonyl ureas, process for preparing them and their use BASF Aktiengesellschaft (DE) 1990-07-18 — — EP disclosed
EP-0373472-A1 Substituted sulfonyl ureas BASF Aktiengesellschaft (DE) 1990-06-20 — — EP disclosed
EP-0291851-A2 Herbicidal sulfonyl urea, process for their preparation and their use as plant growth regulators BASF Aktiengesellschaft (DE) 1988-11-23 — — EP disclosed
US-4657893-A ANTIINFLAMMATORY AGENTS SYNTEX (U.S.A.) INC. (US) 1987-04-14 — — US disclosed
EP-0078003-B1 THIAZOLO (2,3-B)-QUINAZOLONES AND PROCESS FOR THEIR PREPARATION BASF Aktiengesellschaft (DE) 1986-03-05 — — EP disclosed
EP-0147211-A2 4H-3,1-benzoxazin-4-ones and related compounds, pharmaceutical compositions containing them, and processes for their preparation SYNTEX (U.S.A.) INC. (US) 1985-07-03 — — EP disclosed
US-4486221-A POSTEMERGENCE HERBICIDES BASF AKTIENGESELLSCHAFT (DE) 1984-12-04 — — US disclosed
EP-0078003-A2 Thiazolo (2,3-b)-quinazolones and process for their preparation BASF Aktiengesellschaft (DE) 1983-05-04 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250011289-A1 1H-BENZO[B]AZEPIN-2(3H)-ONE COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING CANCER BRCA1, TP53, BCCIP CA12 2599/4885CA1 4113/4885CA2 4453/4885
US-12570655-B2 Cysteine covalent modifiers of AKT1 and uses thereof AKT1, AKT2, AKT3 CA12 1769/4885CA1 1957/4885CA2 1049/4885
US-20250289819-A1 CYSTEINE COVALENT MODIFIERS OF AKT1 AND USES THEREOF AKT1, AKT2, AKT3 CA12 2747/4885CA1 2242/4885CA2 1852/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.