Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PPM1B | O75688 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL52267 | 0.88 | TP53 (0.38) | TP53POLBSMN1; SMN2CHRNB2CHRNA4 | |
| SCHEMBL29362369 | 0.88 | TP53 (0.38) | TP53POLBSMN1; SMN2CHRNB2CHRNA4 | |
| SCHEMBL26929285 | 0.88 | TP53 (0.38) | TP53POLBSMN1; SMN2CHRNB2CHRNA4 | |
| SCHEMBL21466190 | 0.84 | TP53 (0.33) | TP53POLBSMN1; SMN2PPM1BPTPN1 | |
| SCHEMBL17584 | 0.83 | TP53 (0.44) | TP53POLBSMN1; SMN2CHRNB2CHRNA4 | |
| SCHEMBL16035061 | 0.80 | MAPT (0.47) | GAAPPM1BPTPN1PPP1CCALDH1A1 | |
| SCHEMBL15334702 | 0.80 | LMNA (0.41) | GAAPPM1BPTPN1ALDH1A1 | |
| SCHEMBL1653402 | 0.80 | TP53 (0.46) | TP53POLBSMN1; SMN2CHRNB2CHRNA4 | |
| SCHEMBL4915472 | 0.80 | TP53 (0.46) | TP53POLBSMN1; SMN2CHRNB2CHRNA4 | |
| SCHEMBL27028216 | 0.79 | CHRNB2 (0.37) | SMN1; SMN2CHRNB2CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104781238-A | Pyrazole carboxamide compounds, compositions and methods of use | HOFFMANN LA ROCHE | 2015-07-15 | — | — | CN | disclosed |