Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10110583 | 0.87 | GRIN2D (0.37) | PARP1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL29205065 | 0.73 | NAPRT (0.41) | PARP1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL8133747 | 0.72 | PDGFRB (0.43) | PARP1TSHRKMT2AKDM4EALDH1A1 | |
| SCHEMBL9094208 | 0.70 | GABRA1 (0.48) | PARP1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL15782805 | 0.69 | CA12 (0.44) | PARP1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL27588809 | 0.69 | NPSR1 (0.52) | PARP1TSHRALDH1A1HPGDNPSR1 | |
| SCHEMBL8764262 | 0.69 | PARP1 (0.56) | PARP1TSHRHPGDNPSR1EGLN1 | |
| SCHEMBL5227532 | 0.68 | NAPRT (0.53) | TSHRKMT2AKDM4EALDH1A1HPGD | |
| Acetic Acid SCHEMBL27924740 | 0.68 | POLB (0.34) | KMT2AKDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL12473710 | 0.67 | HTR1A (0.38) | PARP1KMT2AKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104703606-B | Use of 1-adamantane ethoxy-3-morpholinyl-2-propanol or a pharmaceutically acceptable salt thereof in a pharmaceutical composition as a neuroretinal protector | 格列布·弗拉基米罗维奇·左格瑞 | 2016-10-12 | — | — | CN | disclosed |
| CN-104703606-A | Use of 1-adamantane ethoxy-3-morpholinyl-2-propanol or a pharmaceutically acceptable salt thereof in a pharmaceutical composition as a neuroretinal protector | ZAGORII GLEB VLADIMIROVICH | 2015-06-10 | — | — | CN | disclosed |