Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 20/20 | 0.88 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.85 |
| ▸ | CCR2 | P41597 | 3/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2801786 | 1.00 | ROCK2 (0.88) | ROCK2ROCK1CCR2 | |
| SCHEMBL4475773 | 0.95 | ROCK2 (0.86) | ROCK2ROCK1CCR2 | |
| SCHEMBL659829 | 0.94 | ROCK2 (1.00) | ROCK2ROCK1CCR2 | |
| SCHEMBL2801887 | 0.94 | ROCK2 (1.00) | ROCK2ROCK1CCR2 | |
| SCHEMBL4471726 | 0.93 | ROCK2 (0.80) | ROCK2ROCK1CCR2 | |
| SCHEMBL3185041 | 0.92 | ROCK2 (1.00) | ROCK2ROCK1CCR2 | |
| SCHEMBL3185054 | 0.92 | ROCK2 (1.00) | ROCK2ROCK1CCR2 | |
| SCHEMBL660606 | 0.92 | ROCK2 (1.00) | ROCK2ROCK1CCR2 | |
| SCHEMBL4465235 | 0.91 | ROCK2 (1.00) | ROCK2ROCK1CCR2 | |
| SCHEMBL3171351 | 0.91 | ROCK2 (0.89) | ROCK2ROCK1CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060167043-A1 | Isoquinoline derivatives having kinasae inhibitory activity and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-07-27 | — | — | US | claimed |
| CN-1694879-A | Isoquinoline derivatives having kinasae inhibitory activity and drugs containing the same | KIRIN BREWERY (JP) | 2005-11-09 | — | — | CN | claimed |
| EP-1550660-A1 | ISOQUINOLINE DERIVATIVES HAVING KINASAE INHIBITORY ACTIVITY AND DRUGS CONTAINING THE SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2005-07-06 | — | — | EP | claimed |
| US-20130172324-A1 | METHOD FOR TREATING CARDIOVASCULAR DISEASES USING RHO KINASE INHIBITOR COMPOUNDS | INSPIRE PHARMACEUTICALS, INC. (US) | 2013-07-04 | — | — | US | disclosed |
| US-8299096-B2 | Method for treating pulmonary diseases using rho kinase inhibitor compounds | INSPIRE PHARMACEUTICALS, INC. (US) | 2012-10-30 | — | — | US | disclosed |
| US-8207195-B2 | Method for treating neurological and neuropathic diseases using rho kinase inhibitor compounds | INSPIRE PHARMACEUTICALS, INC. (US) | 2012-06-26 | — | — | US | disclosed |
| US-20100204210-A1 | METHOD FOR TREATING PULMONARY DISEASES USING RHO KINASE INHIBITOR COMPOUNDS | INSPIRE PHARMACEUTICALS, INC. | 2010-08-12 | — | — | US | disclosed |
| US-20100204210-A1 | METHOD FOR TREATING PULMONARY DISEASES USING RHO KINASE INHIBITOR COMPOUNDS | INSPIRE PHARMACEUTICALS, INC. | 2010-08-12 | — | — | US | disclosed |
| US-20100022517-A1 | OPHTHALMIC FORMULATION OF RHO KINASE INHIBITOR COMPOUND | INSPIRE PHARMACEUTICALS, INC. | 2010-01-28 | — | — | US | disclosed |
| US-20100008968-A1 | METHOD FOR TREATING CARDIOVASCULAR DISEASES USING RHO KINASE INHIBITOR COMPOUNDS | INSPIRE PHARMACEUTICALS, INC. | 2010-01-14 | — | — | US | disclosed |
| US-20090325958-A1 | METHOD FOR TREATING PULMONARY DISEASES USING RHO KINASE INHIBITOR COMPOUNDS | INSPIRE PHARMACEUTICALS, INC. | 2009-12-31 | — | — | US | disclosed |
| US-20090325959-A1 | METHOD FOR TREATING OPHTHALMIC DISEASES USING RHO KINASE INHIBITOR COMPOUNDS | INSPIRE PHARMACEUTICALS, INC. | 2009-12-31 | — | — | US | disclosed |
| US-20090325934-A1 | METHOD FOR TREATING NEUROLOGICAL AND NEUROPATHIC DISEASES USING RHO KINASE INHIBITOR COMPOUNDS | INSPIRE PHARMACEUTICALS, INC. | 2009-12-31 | — | — | US | disclosed |
| US-7615564-B2 | Isoquinoline derivatives having kinasae inhibitory activity and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2009-11-10 | — | — | US | disclosed |
| US-7615564-B2 | Isoquinoline derivatives having kinasae inhibitory activity and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2009-11-10 | — | — | US | disclosed |
| US-7615564-B2 | Isoquinoline derivatives having kinasae inhibitory activity and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2009-11-10 | — | — | US | disclosed |
| CN-100383140-C | Isoquinoline derivatives having kinasae inhibitory activity and drugs containing the same | KIRIN BREWERY (JP) | 2008-04-23 | — | — | CN | disclosed |
| US-20060167043-A1 | Isoquinoline derivatives having kinasae inhibitory activity and drugs containing the same | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-07-27 | — | — | US | disclosed |
| CN-1694879-A | Isoquinoline derivatives having kinasae inhibitory activity and drugs containing the same | KIRIN BREWERY (JP) | 2005-11-09 | — | — | CN | disclosed |
| EP-1550660-A1 | ISOQUINOLINE DERIVATIVES HAVING KINASAE INHIBITORY ACTIVITY AND DRUGS CONTAINING THE SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2005-07-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100008968-A1 | METHOD FOR TREATING CARDIOVASCULAR DISEASES USING RHO KINASE INHIBITOR COMPOUNDS | ROCK1, ROCK2, RHOA | ROCK2 2/4885ROCK1 1/4885CCR2 1028/4885 |
| US-20060167043-A1 | Isoquinoline derivatives having kinasae inhibitory activity and drugs containing the same | ROCK2, MAP4K5, TNK2 | ROCK2 1/4885ROCK1 5/4885CCR2 2249/4885 |
| US-20100022517-A1 | OPHTHALMIC FORMULATION OF RHO KINASE INHIBITOR COMPOUND | ROCK1, ROCK2, CIT | ROCK2 2/4885ROCK1 1/4885CCR2 4070/4885 |
| US-20130172324-A1 | METHOD FOR TREATING CARDIOVASCULAR DISEASES USING RHO KINASE INHIBITOR COMPOUNDS | ROCK1, ROCK2, RHOA | ROCK2 2/4885ROCK1 1/4885CCR2 1028/4885 |
| US-20090325958-A1 | METHOD FOR TREATING PULMONARY DISEASES USING RHO KINASE INHIBITOR COMPOUNDS | ROCK1, RHOA, ROCK2 | ROCK2 3/4885ROCK1 1/4885CCR2 902/4885 |
| US-20090325934-A1 | METHOD FOR TREATING NEUROLOGICAL AND NEUROPATHIC DISEASES USING RHO KINASE INHIBITOR COMPOUNDS | ROCK1, ROCK2, RHOA | ROCK2 2/4885ROCK1 1/4885CCR2 642/4885 |
| US-20100204210-A1 | METHOD FOR TREATING PULMONARY DISEASES USING RHO KINASE INHIBITOR COMPOUNDS | ROCK1, RHOA, SERPINB1 | ROCK2 4/4885ROCK1 1/4885CCR2 785/4885 |
| US-20090325959-A1 | METHOD FOR TREATING OPHTHALMIC DISEASES USING RHO KINASE INHIBITOR COMPOUNDS | ROCK2, ROCK1, CIT | ROCK2 1/4885ROCK1 2/4885CCR2 659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.