Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | GRM8 | O00222 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.30 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1104783 | 0.83 | NOTUM (0.42) | NOTUMGRM8GRM4FKBP5HDAC6 | |
| SCHEMBL24253389 | 0.79 | GRM8 (0.42) | NOTUMGRM8GRM4FKBP5HDAC6 | |
| SCHEMBL19441070 | 0.79 | NOTUM (0.39) | NOTUMGRM8GRM4FKBP5HDAC6 | |
| SCHEMBL28265713 | 0.78 | HDAC6 (0.45) | NOTUMGRM8GRM4FKBP5HDAC6 | |
| SCHEMBL19365913 | 0.76 | HDAC4 (0.46) | NOTUMGRM8GRM4FKBP5NSD2 | |
| SCHEMBL18474686 | 0.73 | GRM8 (0.39) | NOTUMGRM8GRM4NSD2ABL1 | |
| SCHEMBL27377916 | 0.71 | NOTUM (0.37) | NOTUMGRM8GRM4PTGS2 | |
| SCHEMBL28018148 | 0.70 | ALDH1A1 (0.48) | GRM8GRM4FKBP5IDH1 | |
| SCHEMBL13741453 | 0.69 | PTGS2 (0.43) | NOTUMGRM8GRM4L3MBTL1PTGS2 | |
| SCHEMBL25064753 | 0.68 | GRM8 (0.38) | NOTUMGRM8GRM4NSD2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104736535-A | Heterocyclic modulators of hif activity for treatment of disease | JONES PHILIP | 2015-06-24 | — | — | CN | disclosed |