SCHEMBL2801832

SCHEMBL2801832

OC(C#Cc1ccccc1)c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.52
CACNA2D1 P54289 1/20 0.50
CACNB2 Q08289 1/20 0.50
CACNA1C Q13936 1/20 0.50
APP P05067 1/20 0.48
ALDH1A1 P00352 3/20 0.44
MAPK1 P28482 2/20 0.44
LMNA P02545 5/20 0.43
KMT2A Q03164 1/20 0.43
HTT P42858 1/20 0.43
IDO1 P14902 1/20 0.43
GRM5 P41594 1/20 0.40
MAPT P10636 2/20 0.38
FFAR1 O14842 1/20 0.38
KDM4E B2RXH2 1/20 0.38
TP53 P04637 1/20 0.38
POLB P06746 1/20 0.38
PKM P14618 1/20 0.38
HPGD P15428 1/20 0.38
ALOX15 P16050 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2519799 1.00 TSHR (0.52) TSHRCACNA2D1CACNB2CACNA1CAPP
SCHEMBL17845069 0.95 APP (0.48) TSHRCACNA2D1CACNB2CACNA1CAPP
SCHEMBL9132972 0.88 SLC6A2 (0.47) TSHRCACNA2D1CACNB2CACNA1CALDH1A1
SCHEMBL8681264 0.88 CYP1A1 (0.44) TSHRCACNA2D1CACNB2CACNA1CAPP
SCHEMBL2683928 0.86 CACNA2D1 (0.40) TSHRCACNA2D1CACNB2CACNA1CAPP
SCHEMBL2686081 0.86 VCP (0.46) TSHRCACNA2D1CACNB2CACNA1CAPP
SCHEMBL2802726 0.86 CACNA2D1 (0.40) TSHRCACNA2D1CACNB2CACNA1CAPP
SCHEMBL9669350 0.86 HTR2A (0.40) TSHRCACNA2D1CACNB2CACNA1CAPP
SCHEMBL11213850 0.86 TSHR (0.53) TSHRCACNA2D1CACNB2CACNA1CALDH1A1
SCHEMBL29288285 0.86 TSHR (0.44) TSHRCACNA2D1CACNB2CACNA1CALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 95 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107790186-B Novel decamethyl cyclopentadienyl zirconium complex and preparation method and application thereof 山西医科大学 2020-10-30 CN claimed
EP-1438309-A1 QUINUCLIDINE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES AS M2 AND/OR M3 MUSCARINIC RECEPTOR INHIBITORS UCB, S.A. (BE) 2004-07-21 EP claimed
WO-2003033495-A1 QUINUCLIDINE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES AS M2 AND/OR M3 MUSCARINIC RECEPTOR INHIBITORS UCB, S.A. (BE) 2003-04-24 WO claimed
EP-0476658-B1 1-Phenyl-3-phenyl-2-propyne-1-ones MERRELL DOW PHARMA (US) 1995-11-15 EP claimed
EP-0476658-A1 1-Phenyl-3-phenyl-2-propyne-1-ones MERRELL DOW PHARMACEUTICALS INC. (US) 1992-03-25 EP claimed
EP-0302195-B1 PROCESS FOR THE PREPARATION OF NAPHTHACENES AMERICAN CYANAMID COMPANY (US) 1991-06-19 EP claimed
US-4855520-A REACTING A 1,3-DIPHENYLPROPARGYL ALCOHOL WITH AN ALKANESULFONY L HALIDE; HINDERED AMINE BASE AMERICAN CYANAMID COMPANY (US) 1989-08-08 US claimed
EP-0302195-A1 Process for the preparation of naphthacenes AMERICAN CYANAMID COMPANY (US) 1989-02-08 EP claimed
JP-1063534-A None JP disclosed
EP-4240433-A1 MEDICAL SILICONE PRESSURE-SENSITIVE ADHESIVE COMPOSITION Elkem Silicones Shanghai Co., Ltd. (CN) 2023-09-13 EP disclosed
WO-2023165217-A1 1,6-DIYNE COMPOUND AND PREPARATION METHOD THEREFOR, AND PRODUCT OBTAINED USING 1,6-DIYNE COMPOUND AS RAW MATERIAL AND USE THEREOF 中国科学院福建物质结构研究所 2023-09-07 WO disclosed
CN-110483400-B Preparation method of pyrazole derivative 上海应用技术大学 2023-04-28 CN disclosed
CN-110467514-B Preparation method of alpha-halogenated unsaturated aldehyde ketone 上海应用技术大学 2023-03-28 CN disclosed
CN-110483430-B Preparation method of isoxazole derivative 上海应用技术大学 2023-02-10 CN disclosed
EP-0302195-B1 PROCESS FOR THE PREPARATION OF NAPHTHACENES AMERICAN CYANAMID COMPANY (US) 1991-06-19 EP disclosed
US-4855520-A REACTING A 1,3-DIPHENYLPROPARGYL ALCOHOL WITH AN ALKANESULFONY L HALIDE; HINDERED AMINE BASE AMERICAN CYANAMID COMPANY (US) 1989-08-08 US disclosed
US-4855520-A REACTING A 1,3-DIPHENYLPROPARGYL ALCOHOL WITH AN ALKANESULFONY L HALIDE; HINDERED AMINE BASE AMERICAN CYANAMID COMPANY (US) 1989-08-08 US disclosed
EP-0302195-A1 Process for the preparation of naphthacenes AMERICAN CYANAMID COMPANY (US) 1989-02-08 EP disclosed
EP-0302195-A1 Process for the preparation of naphthacenes AMERICAN CYANAMID COMPANY (US) 1989-02-08 EP disclosed
US-4322432-A Cyclopropanecarboxylic acid alkynyl esters, processes for producing them, and their use as pesticides CIBA-GEIGY CORPORATION (US) 1982-03-30 US disclosed