Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Styrene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.74 |
| ▸ | TSHR | P16473 | 3/20 | 0.74 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CHAT | P28329 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Styrene SCHEMBL2862346 | 0.97 | ALDH1A1 (0.78) | ALDH1A1TSHRTDP1TP53RELA | |
| Styrene SCHEMBL27910207 | 0.95 | ALDH1A1 (0.74) | ALDH1A1TSHRTDP1TP53RELA | |
| Styrene SCHEMBL1567316 | 0.95 | ALDH1A1 (0.74) | ALDH1A1TSHRTDP1TP53RELA | |
| Styrene SCHEMBL770534 | 0.89 | ALDH1A1 (0.93) | ALDH1A1TSHRTDP1TP53HDAC8 | |
| Styrene SCHEMBL770535 | 0.89 | ALDH1A1 (0.93) | ALDH1A1TSHRTDP1TP53HDAC8 | |
| Styrene SCHEMBL30683809 | 0.89 | ALDH1A1 (0.93) | ALDH1A1TSHRTDP1TP53HDAC8 | |
| Styrene SCHEMBL7868854 | 0.89 | ALDH1A1 (0.93) | ALDH1A1TSHRTDP1TP53HDAC8 | |
| Styrene SCHEMBL331172 | 0.89 | — | — | |
| Styrene SCHEMBL30598432 | 0.89 | ALDH1A1 (0.93) | ALDH1A1TSHRTDP1TP53HDAC8 | |
| Styrene SCHEMBL7868857 | 0.89 | ALDH1A1 (0.93) | ALDH1A1TSHRTDP1TP53HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105585709-A | Preparation method for organic amine-modified montmorillonite/polyamide nano composite material | Guangdong xinhui meida nylon co ltd | 2016-05-18 | — | — | CN | claimed |
| CN-105585708-A | Nylon composite material reinforced by nano reinforcing particles, preparation method and application thereof | Guangdong xinhui meida nylon co ltd | 2016-05-18 | — | — | CN | claimed |
| CN-104744842-A | Polystyrene composite material reinforced by in situ-polymerization of montmorillonite intercalation and preparation method of polystyrene composite material | HEFEI ORINKO NEW MATERIAL CO LTD | 2015-07-01 | — | — | CN | claimed |
| CN-105585708-B | Nylon composite materials of nanometer enhancing particulate reinforcement and its preparation method and application | 广东新会美达锦纶股份有限公司 | 2018-07-03 | — | — | CN | disclosed |
| CN-105585709-B | The preparation method of organic amine modified montmorillonoid/polyamide nano-composite | 广东新会美达锦纶股份有限公司 | 2018-06-29 | — | — | CN | disclosed |
| CN-105585709-A | Preparation method for organic amine-modified montmorillonite/polyamide nano composite material | Guangdong xinhui meida nylon co ltd | 2016-05-18 | — | — | CN | disclosed |
| CN-105585708-A | Nylon composite material reinforced by nano reinforcing particles, preparation method and application thereof | Guangdong xinhui meida nylon co ltd | 2016-05-18 | — | — | CN | disclosed |
| CN-104744842-A | Polystyrene composite material reinforced by in situ-polymerization of montmorillonite intercalation and preparation method of polystyrene composite material | HEFEI ORINKO NEW MATERIAL CO LTD | 2015-07-01 | — | — | CN | disclosed |