Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.44 |
| ▸ | HTR2B | P41595 | 8/20 | 0.44 |
| ▸ | HTR2A | P28223 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PPID | Q08752 | 1/20 | 0.37 |
| ▸ | PPIG | Q13427 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8670992 | 0.86 | HTR2C (0.43) | HTR2CHTR2BHTR2AMTNR1AMTNR1B | |
| SCHEMBL28018756 | 0.74 | KDM4E (0.42) | MEN1KMT2ARCE1MTNR1AMTNR1B | |
| SCHEMBL5333905 | 0.72 | HTR2C (0.47) | HTR2CHTR2BHTR2ATAAR1MAPK1 | |
| SCHEMBL30873752 | 0.72 | TACR1 (0.43) | HTR2CHTR2BHTR2ATAAR1MAPK1 | |
| SCHEMBL29135380 | 0.71 | NR1H2 (0.38) | HTR2CHTR2BHTR2AMEN1KMT2A | |
| SCHEMBL14856667 | 0.71 | MAPT (0.42) | MEN1KMT2APKM | |
| SCHEMBL30969012 | 0.71 | CCR8 (0.39) | MEN1KMT2A | |
| SCHEMBL16466085 | 0.71 | OPRD1 (0.44) | MEN1KMT2AKDM4EMAPK1 | |
| SCHEMBL30502301 | 0.71 | HTR2C (0.44) | HTR2CHTR2BHTR2ATAAR1MAPK1 | |
| SCHEMBL29773837 | 0.71 | IDO1 (0.43) | HTR2CHTR2BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104837821-B | Acylpiperazines as inhibitors of transglutaminase and their use in medicine | 阿斯顿大学 | 2018-11-13 | — | — | CN | disclosed |
| CN-104837821-A | Acylpiperazines as inhibitors of transglutaminase and their use in medicine | UNIV ASTON | 2015-08-12 | — | — | CN | disclosed |