Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.43 |
| ▸ | HTR2B | P41595 | 8/20 | 0.43 |
| ▸ | HTR2A | P28223 | 7/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28019268 | 0.86 | HTR2C (0.44) | HTR2CHTR2BHTR2AMAPK1MTNR1A | |
| SCHEMBL2404066 | 0.78 | HTR2C (0.54) | HTR2CHTR2BHTR2A | |
| SCHEMBL1580100 | 0.77 | POLB (0.54) | MAPK1TAAR1TSHR | |
| Hydrochloric Acid SCHEMBL2847260 | 0.74 | TACR1 (0.47) | HTR2CHTR2BHTR2A | |
| SCHEMBL29564745 | 0.73 | MTNR1A (0.44) | MAPK1MTNR1AMTNR1BCYP1A2CYP2D6 | |
| SCHEMBL8670994 | 0.73 | TDP1 (0.42) | HTR2CHTR2BHTR2AMTNR1ATAAR1 | |
| SCHEMBL18284815 | 0.71 | TAAR1 (0.44) | HTR2CHTR2BHTR2ATAAR1 | |
| SCHEMBL2697639 | 0.71 | HTR2A (0.39) | HTR2CHTR2BHTR2AMTNR1ATAAR1 | |
| SCHEMBL3338258 | 0.71 | LMNA (0.44) | HTR2CHTR2BHTR2A | |
| SCHEMBL15824978 | 0.70 | TAAR1 (0.43) | HTR2CHTR2BHTR2ATAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880512-A1 | NOVEL AROMATIC PIPERAZINES DERIVED FROM SUBSTITUTED CYCLOAZANES, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF AS DRUGS | PIERRE FABRE MEDICAMENT (FR) | 1998-12-02 | — | — | EP | disclosed |
| WO-1997028141-A1 | NOVEL AROMATIC PIPERAZINES DERIVED FROM SUBSTITUTED CYCLOAZANES, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITIONS, AND USE THEREOF AS DRUGS | PIERRE FABRE MEDICAMENT (FR) | 1997-08-07 | — | — | WO | disclosed |